Antioxidant Effects of a Hydroxytyrosol-Based Pharmaceutical Formulation on Body Composition, Metabolic State, and Gene Expression: A Randomized Double-Blinded, Placebo-Controlled Crossover Trial

被引：68

作者：

Colica, Carmela ^{[1
]}

Di Renzo, Laura ^{[2
]}

Trombetta, Domenico ^{[3
]}

Smeriglio, Antonella ^{[3
]}

Bernardini, Sergio ^{[4
]}

Cioccoloni, Giorgia ^{[5
]}

de Miranda, Renata Costa ^{[5
]}

Gualtieri, Paola ^{[5
]}

Salimei, Paola Sinibaldi ^{[2
]}

De Lorenzo, Antonino ^{[2
]}

机构：

[1] Magna Graecia Univ Catanzaro, IBFM UOS Germaneto, CNR, Campus Salvatore Venuta, I-88100 Catanzaro, Italy

[2] Univ Roma Tor Vergata, Dept Biomed & Prevent, Sect Clin Nutr & Nutrigen, Via Montpellier 1, I-00133 Rome, Italy

[3] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale F Stagno Alcontres 31, Messina, Italy

[4] Univ Roma Tor Vergata, Div Clin Biochem & Clin Mol Biol, Rome, Italy

[5] Univ Roma Tor Vergata, PhD Sch Appl Med Surg Sci, Via Montpellier 1, I-00133 Rome, Italy

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2017年 / 2017卷

关键词：

VIRGIN OLIVE OIL; LOW-DENSITY-LIPOPROTEIN; PHENOLIC-COMPOUNDS; OXIDATIVE STRESS; MEDITERRANEAN DIET; LIPID PROFILE; HEART-DISEASE; PLASMA; BLOOD; FOOD;

D O I：

10.1155/2017/2473495

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hydroxytyrosol (HT) plays a significant role in cardiovascular disease (CVD) protection, and its metabolites are able to protect from the endothelial dysfunction commonly present in atherosclerosis. This randomized double-blinded, placebo-controlled crossover trial determined the effect in healthy volunteers of two gastroresistant capsules containing 15 mg/day of HT, for a 3-week period (HTT). Evaluation of nutritional status, serum metabolites, oxidative stress biomarkers, and gene expression of 9 genes related to oxidative stress, inflammation, and CVDs was performed. Oxidation biomarkers like thiol group (p = 0 001), total antioxidant status (TAS) (p = 0 001), superoxide dismutase 1 (SOD1) (2-(Delta Delta Ct) = 3.7), and plasma concentration of HT (2.83 mu g.mL(-1)) were significantly increased, while nitrite (p = 0 001), nitrate (p = 0 001), and malondialdehyde (MDA) (p = 0 02) were drastically reduced after HTT. A significant reduction of body fat mass percentage (p = 0 01), suprailiac skinfold (p = 0 01), and weight (p = 0 04;Delta%=-0.46%) was observed after HTT. This study shows that regular intake of 15 mg/day of HT changed body composition parameters and modulated the antioxidant profile and the expression of inflammation and oxidative stress-related genes. However, it is advisable to personalize HT doses in order to exert its health benefits in CVD prevention and protection of LDL-C particles from oxidative damage.

引用

页数：14

共 69 条

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