Antimicrobial peptides and wound healing: biological and therapeutic considerations

被引：288
作者：
Mangoni, Maria Luisa [1 ]
McDermott, Alison M. [2 ]
Zasloff, Michael [3 ]
机构：
[1] Univ Roma La Sapienza, Fdn Cenci Bolognetti, Ist Pasteur, Dept Biochem Sci A Rossi Fanelli, Piazzale Aldo Moro 5, I-00185 Rome, Italy
[2] Univ Houston, Coll Optometry, Ocular Surface Inst, Houston, TX USA
[3] Georgetown Univ Hosp, MedStar Georgetown Transplant Inst, Washington, DC 20007 USA
来源：
EXPERIMENTAL DERMATOLOGY | 2016年 / 25卷 / 03期
关键词：
antibiotic resistance; antimicrobial peptide; frog skin; innate immunity; skin infections; wound healing; HOST-DEFENSE PEPTIDES; SOFT-TISSUE INFECTIONS; HUMAN BETA-DEFENSINS; HUMAN SKIN; FROG-SKIN; IN-VITRO; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; INNATE DEFENSE; KERATINOCYTE MIGRATION;
D O I：
10.1111/exd.12929
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Repair of tissue wounds is a fundamental process to reestablish tissue integrity and regular function. Importantly, infection is a major factor that hinders wound healing. Multicellular organisms have evolved an arsenal of host-defense molecules, including antimicrobial peptides (AMPs), aimed at controlling microbial proliferation and at modulating the host's immune response to a variety of biological or physical insults. In this brief review, we provide the evidence for a role of AMPs as endogenous mediators of wound healing and their promising therapeutic potential for the treatment of non-life-threatening skin and other epithelial injuries.
引用
收藏
页码：167 / 173
页数：7
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