Antimicrobial peptides and wound healing: biological and therapeutic considerations

被引：313

作者：

Mangoni, Maria Luisa ^{[1
]}

McDermott, Alison M. ^{[2
]}

Zasloff, Michael ^{[3
]}

机构：

[1] Univ Roma La Sapienza, Fdn Cenci Bolognetti, Ist Pasteur, Dept Biochem Sci A Rossi Fanelli, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[2] Univ Houston, Coll Optometry, Ocular Surface Inst, Houston, TX USA

[3] Georgetown Univ Hosp, MedStar Georgetown Transplant Inst, Washington, DC 20007 USA

来源：

EXPERIMENTAL DERMATOLOGY | 2016年 / 25卷 / 03期

关键词：

antibiotic resistance; antimicrobial peptide; frog skin; innate immunity; skin infections; wound healing; HOST-DEFENSE PEPTIDES; SOFT-TISSUE INFECTIONS; HUMAN BETA-DEFENSINS; HUMAN SKIN; FROG-SKIN; IN-VITRO; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; INNATE DEFENSE; KERATINOCYTE MIGRATION;

D O I：

10.1111/exd.12929

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Repair of tissue wounds is a fundamental process to reestablish tissue integrity and regular function. Importantly, infection is a major factor that hinders wound healing. Multicellular organisms have evolved an arsenal of host-defense molecules, including antimicrobial peptides (AMPs), aimed at controlling microbial proliferation and at modulating the host's immune response to a variety of biological or physical insults. In this brief review, we provide the evidence for a role of AMPs as endogenous mediators of wound healing and their promising therapeutic potential for the treatment of non-life-threatening skin and other epithelial injuries.

引用

页码：167 / 173

页数：7

共 169 条

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