Peripartum Cardiomyopathy

被引:261
作者
Arany, Zolt [1 ]
Elkayam, Uri [2 ,3 ]
机构
[1] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
[2] Univ So Calif, Dept Med, Div Cardiovas Med, Los Angeles, CA USA
[3] Univ So Calif, Dept Obstet & Gynecol, Los Angeles, CA 90089 USA
关键词
cardiomyopathies; heart failure; pre-eclampsia; pregnancy; MECHANICAL CIRCULATORY SUPPORT; VENTRICULAR EJECTION FRACTION; INTRAVENOUS IMMUNE GLOBULIN; HEART-FAILURE ASSOCIATION; CARDIOLOGY WORKING GROUP; AFRICAN-AMERICAN WOMEN; CLINICAL CHARACTERISTICS; MEMBRANE-OXYGENATION; FAMILIAL OCCURRENCE; RACIAL-DIFFERENCES;
D O I
10.1161/CIRCULATIONAHA.115.020491
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Peripartum cardiomyopathy is a potentially life-threatening pregnancy-associated disease that typically arises in the peripartum period and is marked by left ventricular dysfunction and heart failure. The disease is relatively uncommon, but its incidence is rising. Women often recover cardiac function, but long-lasting morbidity and mortality are not infrequent. Management of peripartum cardiomyopathy is largely limited to the same neurohormonal antagonists used in other forms of cardiomyopathy, and no proven disease-specific therapies exist yet. Research in the past decade has suggested that peripartum cardiomyopathy is caused by vascular dysfunction, triggered by late-gestational maternal hormones. Most recently, information has also indicated that many cases of peripartum cardiomyopathy have genetic underpinnings. We review here the known epidemiology, clinical presentation, and management of peripartum cardiomyopathy, as well as the current knowledge of the pathophysiology of the disease.
引用
收藏
页码:1397 / 1409
页数:13
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