Focal Laser Ablation for Prostate Cancer Followed by Radical Prostatectomy: Validation of Focal Therapy and Imaging Accuracy

被引：133

作者：

Lindner, Uri ^{[1
]}

Lawrentschuk, Nathan ^{[1
]}

Weersink, Robert A. ^{[2
]}

Davidson, Sean R. H. ^{[2
]}

Raz, Orit ^{[1
]}

Hlasny, Eugen ^{[3
]}

Langer, Deanna L. ^{[3
]}

Gertner, Mark R. ^{[2
]}

Van der Kwast, Theodorus ^{[4
]}

Haider, Masoom A. ^{[3
]}

Trachtenberg, John ^{[1
]}

机构：

[1] Univ Toronto, Div Urol, Univ Hlth Network, Toronto, ON, Canada

[2] Univ Hlth Network, Ontario Canc Inst, Div Biophys & Bioimaging, Toronto, ON, Canada

[3] Univ Toronto, Univ Hlth Network, Joint Dept Med Imaging, Toronto, ON, Canada

[4] Univ Toronto, Dept Pathol, Univ Hlth Network, Toronto, ON, Canada

来源：

EUROPEAN UROLOGY | 2010年 / 57卷 / 06期

关键词：

Focal ablation; MRI; Laser; Pathology; Prostate cancer; INTENSITY FOCUSED ULTRASOUND; CRYOTHERAPY;

D O I：

10.1016/j.eururo.2010.03.008

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

An increased incidence of low-risk prostate cancer (PCa) has led investigators to develop focal therapy as a management option for PCa. We evaluated the effects of focal laser ablation (FLA) on PCa tissue and the accuracy of magnetic resonance imaging (MRI) in determining ablated lesion volume by comparing the whole-mount histology and MRI in four patients that underwent FLA followed by radical prostatectomy. Ablated areas were characterized by homogeneous coagulation necrosis. The MRI-calculated ablated volume correlated well with histopathology. We found that FLA creates confluent ablation with no evidence of viable cells in treated regions. Postablation MRI is able to determine the ablation accurately. (c) 2010 European Association of Urology. Published by Elsevier B. V. All rights reserved.

引用

页码：1111 / 1114

页数：4

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