Serum Levels of Adiponectin and Leptin in Children Born Small for Gestational Age: Relation to Insulin Sensitivity Parameters

被引：25
作者：
Miras, Mirta
Ochetti, Mariana
Martin, Silvia
Silvano, Liliana
Sobrero, Gabriela
Castro, Laura
Onassis, Mariana
Tolosa de Talamoni, Nori [1 ]
Perez, Adriana [1 ]
Picotto, Gabriela [1 ]
Diaz de Barboza, Gabriela [1 ]
Munoz, Liliana
机构：
[1] Univ Nacl Cordoba, Fac Ciencias Med, Lab Dr Canas Catedra Bioquim & Biol Mol, RA-5000 Cordoba, Argentina
来源：
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2010年 / 23卷 / 05期
关键词：
small for gestational age children; insulin sensitivity; adiponectin; leptin; CATCH-UP GROWTH; DEPENDENT DIABETES-MELLITUS; INTRAUTERINE GROWTH; PROSPECTIVE COHORT; BODY-COMPOSITION; METABOLIC SYNDROME; FINAL HEIGHT; FACTOR-I; INFANTS; OBESITY;
D O I：
10.1515/jpem.2010.077
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Children born small for gestational age (SGA) are prone to developing obesity, insulin resistance and type 2 diabetes. Adiponectin and leptin are adipocytokines associated with insulin sensitivity parameters. We aimed to relate serum adiponectin and leptin levels with insulin sensitivity parameters in prepuberal SGA children with and without catch-up growth (SGA+CUG; SGA-CUG, respectively) and to analyze the usefulness of these adipocytokines as early markers of insulin resistance. We analysed adiponectin, proinsulin, leptin, growth factors, insulin, HOMA IR and HOMA beta cell in 23 SGA+CUG, 26 SGA-CUG children compared with 48 prepuberal appropiate for gestational age (AGA). SGA children had adiponectin levels comparable to AGA children. Leptin levels were different between sexes, showed to be higher in SGA+CUG group (p=0.040) and these were significantly correlated with insulin sensitivity parameters. These results suggest leptin resistance as an adaptive mechanism to increase energy balance, but an altered functional response of adipocytes cannot be discarded.
引用
收藏
页码：463 / 471
页数：9
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