CD44 polymorphisms and its variants, as an inconsistent marker in cancer investigations

被引：33

作者：

Gomari, Mohammad Mahmoudi ^{[1
]}

Farsimadan, Marziye ^{[2
]}

Rostami, Neda ^{[3
]}

Mahmoudi, Zahra ^{[1
]}

Fadaie, Mahmood ^{[4
]}

Farhani, Ibrahim ^{[5
]}

Tarighi, Parastoo ^{[1
]}

机构：

[1] Iran Univ Med Sci, Fac Allied Med, Dept Med Biotechnol, Tehran, Iran

[2] Univ Guilan, Dept Biol, Fac Sci, Rasht, Iran

[3] Arak Univ, Fac Engn, Dept Chem Engn, Arak, Iran

[4] Isfahan Univ Med Sci, Dept Genet & Mol Biol, Sch Med, Esfahan, Iran

[5] Golestan Univ Med Sci, Fac Adv Technol Med, Dept Med Biotechnol, Gorgan, Golestan, Iran

来源：

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH | 2021年 / 787卷

关键词：

CD44; Single nucleotide polymorphism; Cancer marker; Cancer prognosis; STEM-CELL MARKER; SINGLE-NUCLEOTIDE POLYMORPHISMS; TUMOR-INITIATING CELLS; THAN-T POLYMORPHISM; GASTRIC-CANCER; BREAST-CANCER; OVARIAN-CANCER; LUNG-CANCER; POOR-PROGNOSIS; GENE VARIANTS;

D O I：

10.1016/j.mrrev.2021.108374

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Among cell surface markers, CD44 is considered the main marker for identifying and isolating the cancer stem cells (CSCs) among other cells and has attracted significant attention in avariety of research areas. Many studies have shown the essential roles of CD44 in initiation, metastasis, and tumorigenesis in different types of cancer; however, the validity of CD44 as a therapeutic or diagnostic target has not been fully confirmed in some other studies. Whereas the association of specific single nucleotide polymorphisms (SNPs) in the CD44 gene and related variants with cancer risk have been observed in clinical investigations, the significance of these findings remains controversial. Here, we aimed to provide an up-to-date overview of recent studies on the association of CD44 polymorphisms and its variants with different kinds of cancer to determine whether or not it can be used as an appropriate candidate for cancer tracking. (c) 2021 Elsevier B.V. All rights reserved.

引用

页数：13

共 182 条

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