Thermoresponsive hydrogels from alginate-based graft copolymers

被引：70

作者：

Soledad Lencina, M. M. ^{[1
,2
]}

Iatridi, Zacharoula ^{[2
]}

Villar, Marcelo A. ^{[1
]}

Tsitsilianis, Constantinos ^{[2
,3
]}

机构：

[1] PLAPIQUI UNS CONICET, RA-8000 Bahia Blanca, Buenos Aires, Argentina

[2] Univ Patras, Dept Chem Engn, Patras 26504, Greece

[3] ICE HT FORTH, Inst Chem Engn Sci, Patras 26504, Greece

来源：

EUROPEAN POLYMER JOURNAL | 2014年 / 61卷

关键词：

Alginate; P(N-isopropylacrylamide); N-tert-butylacrylamide comonomer; Graft copolymers; Thermosensitive; Hydrogels; N-ISOPROPYLACRYLAMIDE; RESPONSIVE BEHAVIORS; PHASE-TRANSITION; AQUEOUS-SOLUTION; SODIUM ALGINATE; DRUG-DELIVERY; POLY(N-ISOPROPYLACRYLAMIDE); TEMPERATURE; CHITOSAN; BEADS;

D O I：

10.1016/j.eurpolymj.2014.09.011

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Three samples of sodium alginate grafted by amino-terminated PNIPAM (low and high molecular weight poly(N-isopropylacrylamide)) and a random P(NIPAM-co-NtBAM) (NtBAM: N-tertiary butyl acrylamide) copolymer, were synthesized via the carbodiimide chemistry and their temperature-induced hydrogelation capability was evaluated by rheology. All the samples showed thermothickening behaviour depending on concentration, ionic strength and hydrophobic comonomer content, incorporated to the PNIPAM thermo-sensitive pendant chains. The main result of this study was that a slight hydrophobic enrichment (just 15 mol% NtBAM) of PNIPAM was sufficient to shift the gelation temperature well below the physiological temperature at 32 degrees C and at the lowest polymer concentration studied (i.e. 10 wt%). The consequence of that was that the ALG-g-P(NIPAM-co-NtBAM) graft copolymer hydrogel exhibited the best rheological thermo-responsive properties and might be used as injectable hydrogel for potential applications in biomedicine. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：33 / 44

页数：12

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