The protective effect of edaravone on memory impairment induced by chronic sleep deprivation

被引：21
作者：
Alzoubi, Karem H. [1 ]
Al Mosabih, Heba S. [2 ]
Mahasneh, Amjad F. [2 ]
机构：
[1] Jordan Univ Sci & Technol, Dept Clin Pharm, Irbid, Jordan
[2] Jordan Univ Sci & Technol, Dept Appl Biol, Irbid, Jordan
来源：
PSYCHIATRY RESEARCH | 2019年 / 281卷
关键词：
Edaravone; Sleep deprivation; Memory; Maze; Oxidative stress; LONG-TERM-MEMORY; HIPPOCAMPAL OXIDATIVE STRESS; ALZHEIMERS-DISEASE BRAIN; RADICAL SCAVENGER; REM-SLEEP; SPATIAL MEMORY; PREVENTS; CONSOLIDATION; DEFICITS; BDNF;
D O I：
10.1016/j.psychres.2019.112577
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Sleep plays a critical role in body health maintenance, whereas sleep deprivation (SD) negatively affects cognitive function. Cognitive defects mainly memory impairment resulting from sleep deprivation were related to an increase in the level of oxidative stress in the body, including the brain hippocampus region. Edaravone is a potent free radical scavenger having antioxidant effect. In the current study, edaravone's ability to prevent SD induced cognitive impairment was tested in rats. Animals were sleep deprived 8 h/day for 4 weeks. Concurrently, edaravone was administrated intraperitoneally for four weeks. Animals performance during cognitive testing was evaluated to display if edaravone has a role in the prevention of sleep deprivation induced memory impairment. Additionally, the role of antioxidant biomarkers glutathione peroxidase (GPx), catalase, glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG in this effect was investigated. The results showed that SD impaired both short- and long- term memories, and chronic edaravone administration prevented such effect. Additionally, edaravone prevented decreases in hippocampal GPx, catalase, GSH/GSSG ratio and normalized increases in GSSG levels, which were impaired by SD model. In conclusion, current result showed a protective effect of edaravone administration against SD induction that could be related to edaravone's ability to normalizing mechanisms related to oxidative balance.
引用
收藏
页数：7
相关论文
共 55 条
[1]   Post-learning REM sleep deprivation impairs long-term memory: Reversal by acute nicotine treatment [J].
Aleisa, A. M. ;
Alzoubi, K. H. ;
Alkadhi, K. A. .
NEUROSCIENCE LETTERS, 2011, 499 (01) :28-31
[2]   Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: Protection by caffeine [J].
Alhaider, Ibrahim A. ;
Aleisa, Abdulaziz M. ;
Tran, Trinh T. ;
Alkadhi, Karim A. .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2011, 46 (04) :742-751
[3]   Caffeine prevents sleep loss-induced deficits in long-term potentiation and related signaling molecules in the dentate gyrus [J].
Alhaider, Ibrahim A. ;
Aleisa, Abdulaziz M. ;
Tran, Trinh T. ;
Alkadhi, Karim A. .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2010, 31 (08) :1368-1376
[4]   Chronic Caffeine Treatment Prevents Sleep Deprivation-Induced Impairment of Cognitive Function and Synaptic Plasticity [J].
Alhaider, Ibrahim A. ;
Aleisa, Abdulaziz M. ;
Tran, Trinh T. ;
Alzoubi, Karem H. ;
Alkadhi, Karim A. .
SLEEP, 2010, 33 (04) :437-444
[5]   Neurobiological Consequences of Sleep Deprivation [J].
Alkadhi, Karim ;
Zagaar, Munder ;
Alhaider, Ibrahim ;
Salim, Samina ;
Aleisa, Abdulaziz .
CURRENT NEUROPHARMACOLOGY, 2013, 11 (03) :231-249
[6]   Omega-3 Fatty Acids Prevent Post-Traumatic Stress Disorder-Induced Memory Impairment [J].
Alquraan, Laiali ;
Alzoubi, Karem H. ;
Hammad, Hana ;
Rababa'h, Suzie Y. ;
Mayyas, Fadia .
BIOMOLECULES, 2019, 9 (03)
[7]   Caffeine prevents cognitive impairment induced by chronic psychosocial stress and/or high fat-high carbohydrate diet [J].
Alzoubi, K. H. ;
Abdul-Razzak, K. K. ;
Khabour, O. F. ;
Al-Tuweiq, G. M. ;
Alzubi, M. A. ;
Alkadhi, K. A. .
BEHAVIOURAL BRAIN RESEARCH, 2013, 237 :7-14
[8]   Molecular targets for the interactive effect of etazolate during post-traumatic stress disorder: Role of oxidative stress, BDNF and histones [J].
Alzoubi, Karem H. ;
Al Subeh, Zeinab Y. ;
Khabour, Omar F. .
BEHAVIOURAL BRAIN RESEARCH, 2019, 369
[9]   Omega-3 fatty acids protects against chronic sleep-deprivation induced memory impairment [J].
Alzoubi, Karem H. ;
Mayyas, Fadia ;
Abu Zamzam, Hamza, I .
LIFE SCIENCES, 2019, 227 :1-7
[10]   Edaravone prevents memory impairment in an animal model of post-traumatic distress [J].
Alzoubi, Karem H. ;
Shatnawi, Alaa ;
Al-Qudah, Mohammad A. ;
Alfaqih, Mahmoud A. .
BEHAVIOURAL PHARMACOLOGY, 2019, 30 (2-3) :201-207
123456