Expansion of CD56Bright natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta

被引：106
作者：
Saraste, M.
Irjala, H.
Airas, L.
机构：
[1] Univ Turku, Dept Neurol, FIN-20521 Turku, Finland
[2] Univ Turku, Dept Otorhinolaryngol, Turku, Finland
[3] Univ Turku, MediCity Res Lab, Turku, Finland
来源：
NEUROLOGICAL SCIENCES | 2007年 / 28卷 / 03期
关键词：
interferon-beta; multiple sclerosis; NK cell; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; NK CELLS; T-CELLS; REGULATORY ROLE; DISEASE; BIOLOGY; GAMMA; IL-2;
D O I：
10.1007/s10072-007-0803-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We studied how interferon-beta (IFN-beta) treatment of relapsing-remitting multiple sclerosis (MS) affects subgroups of natural killer cells (NK cells). Following IFN-beta treatment, there was an expansion of CD56(Bright) NK-cells in the peripheral blood of MS patients, while at the same time the proportion of CD56(Dim) cells was diminished. In a control group, the proportion of CD56(Bright) NK-cells was significantly higher in secondary lymphoid tissues compared to the peripheral blood of the same individual. Our findings confirm that CD56(Bright) NK-cells preferably locate within the secondary lymphoid tismes, where they may interact with T cells and thereby contribute to the control of the disease activity in MS.
引用
收藏
页码：121 / 126
页数：6
相关论文
共 50 条
  • [1] Expansion of CD56Bright natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta
    M. Saraste
    H. Irjala
    L. Airas
    Neurological Sciences, 2007, 28 : 121 - 126
  • [2] CD56bright Natural Killer Cells: A Possible Biomarker of Different Treatments in Multiple Sclerosis
    Laroni, Alice
    Uccelli, Antonio
    JOURNAL OF CLINICAL MEDICINE, 2020, 9 (05)
  • [3] Reduction of the Peripheral Blood CD56bright NK Lymphocyte Subset in FTY720-Treated Multiple Sclerosis Patients
    Johnson, Trina A.
    Evans, Barbara L.
    Durafourt, Bryce A.
    Blain, Manon
    Lapierre, Yves
    Bar-Or, Amit
    Antel, Jack P.
    JOURNAL OF IMMUNOLOGY, 2011, 187 (01) : 570 - 579
  • [4] Natural killer receptors distribution in multiple sclerosis: Relation to clinical course and interferon-beta therapy
    Martinez-Rodriguez, J. E.
    Saez-Borderias, A.
    Munteis, E.
    Romo, N.
    Roquer, J.
    Lopez-Botet, M.
    CLINICAL IMMUNOLOGY, 2010, 137 (01) : 41 - 50
  • [5] Antibodies to commercially available interferon-beta molecules in multiple sclerosis patients treated with natural interferon-beta
    Mayorga, C
    Luque, G
    Romero, F
    Guerrero, R
    Blanca, M
    Fernandez, O
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1999, 118 (2-4) : 368 - 371
  • [6] Natural killer cell phenotype and clinical response to interferon-beta therapy in multiple sclerosis
    Martinez-Rodriguez, J. E.
    Lopez-Botet, M.
    Munteis, E.
    Rio, J.
    Roquer, J.
    Montalban, X.
    Comabella, M.
    CLINICAL IMMUNOLOGY, 2011, 141 (03) : 348 - 356
  • [7] Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+Foxp3 expression in subjects with multiple sclerosis
    Vandenbark, Arthur A.
    Huan, Jianya
    Agotsch, Marisa
    La Tocha, Dorian
    Goelz, Susan
    Offner, Halina
    Lanker, Stefan
    Bourdette, Dennis
    JOURNAL OF NEUROIMMUNOLOGY, 2009, 215 (1-2) : 125 - 128
  • [8] Interferon-beta modifies the peripheral blood cell cytokine secretion in patients with multiple sclerosis
    Mirandola, Sandra R.
    Hallal, Dannie E. M.
    Farias, Alessandro S.
    Oliveira, Elaine C.
    Brandao, Carlos O.
    Ruocco, Heloisa H.
    Damasceno, Benito P.
    Santos, Leonilda M. B.
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2009, 9 (7-8) : 824 - 830
  • [9] Dysregulation of regulatory CD56bright NK cells/T cells interactions in multiple sclerosis
    Laroni, Alice
    Armentani, Eric
    de Rosbo, Nicole Kerlero
    Ivaldi, Federico
    Marcenaro, Emanuela
    Sivori, Simona
    Gandhi, Roopali
    Weiner, Howard L.
    Moretta, Alessandro
    Mancardi, Giovanni L.
    Uccelli, Antonio
    JOURNAL OF AUTOIMMUNITY, 2016, 72 : 8 - 18
  • [10] Expansion of circulating CD56bright natural killer cells in patients with JAK2-positive chronic myeloproliferative neoplasms during treatment with interferon-α
    Riley, Caroline H.
    Hansen, Morten
    Brimnes, Marie K.
    Hasselbalch, Hans C.
    Bjerrum, Ole W.
    Straten, Per Thor
    Svane, Inge Marie
    Jensen, Morten Krogh
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2015, 94 (03) : 227 - 234
12345