Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway

被引：33

作者：

Tang, Lisha ^{[1
]}

Zhu, Hengrui ^{[1
,2
]}

Yang, Xianmei ^{[1
]}

Xie, Fang ^{[1
,3
]}

Peng, Jingtao ^{[4
]}

Jiang, Deke ^{[1
,5
]}

Xie, Jun ^{[1
]}

Qi, Meiyan ^{[1
,6
]}

Yu, Long ^{[1
]}

机构：

[1] Fudan Univ, State Key Lab Genet Engn, Sch Life Sci, Shanghai 200433, Peoples R China

[2] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA

[3] Mayo Clin, Rochester, MN 55905 USA

[4] Shanghai Jiao Tong Univ, Dept Urol, Shanghai Peoples Hosp 1, Shanghai 200030, Peoples R China

[5] Univ Chicago, Program Personalized Canc Care, NorthShore Univ HealthSyst, Pritzker Sch Med, Chicago, IL 60637 USA

[6] Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China

来源：

PLOS ONE | 2016年 / 11卷 / 03期

基金：

中国国家自然科学基金;

关键词：

CHEMICAL-CONSTITUENTS; EXPRESSION; APOPTOSIS; JAPONICUS; PRODUCTS; TARGET; PLANTS;

D O I：

10.1371/journal.pone.0152012

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Natural products have become sources of developing new drugs for the treatment of cancer. To seek candidate compounds that inhibit the growth of liver cancer, components of Chloranthus serratus were tested. Here, we report that shizukaol D, a dimeric sesquiterpene from Chloranthus serratus, exerted a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner. We demonstrated that shizukaol D induced cells to undergo apoptosis. More importantly, shizukaol D attenuated Wnt signalling and reduced the expression of endogenous Wnt target genes, which resulted in decreased expression of beta-catenin. Collectively, this study demonstrated that shizukaol D inhibited the growth of liver cancer cells by modulating Wnt pathway.

引用

页数：13

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