Fission yeast synaptobrevin is involved in cytokinesis and cell elongation

被引：40
|
作者：
Edamatsu, M [1 ]
Toyoshima, YY [1 ]
机构：
[1] Univ Tokyo, Grad Sch Arts & Sci, Meguro Ku, Tokyo 1538902, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 301卷 / 03期
关键词：
Schizosaccharomyces pombe; fission yeast; cytokinesis; membrane trafficking; SNARE; synaptobrevin;
D O I：
10.1016/S0006-291X(03)00017-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Synaptobrevin is a vesicle-associated membrane protein playing an essential role in regulated vesicle transport. In this study, we characterized Syb1, synaptobrevin of Schizosaccharomyces pombe. Syb1 was located on various sizes of vesicle-like structures in the cytoplasm and enriched in the medial region and cell ends. Transport of Syb1 to the medial region was mainly dependent on F-actin and Myo52/Myo4. Syb1 is essential for cell viability and most of the syb1-null cells showed a round or short cylindrical form. These results suggest that Syb1 is involved in membrane trafficking of cytokinesis and cell elongation. (C) 2003 Elsevier Science (USA). All rights reserved.
引用
收藏
页码：641 / 645
页数：5
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