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Fission yeast synaptobrevin is involved in cytokinesis and cell elongation
被引:40
|作者:
Edamatsu, M
[1
]
Toyoshima, YY
[1
]
机构:
[1] Univ Tokyo, Grad Sch Arts & Sci, Meguro Ku, Tokyo 1538902, Japan
关键词:
Schizosaccharomyces pombe;
fission yeast;
cytokinesis;
membrane trafficking;
SNARE;
synaptobrevin;
D O I:
10.1016/S0006-291X(03)00017-2
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Synaptobrevin is a vesicle-associated membrane protein playing an essential role in regulated vesicle transport. In this study, we characterized Syb1, synaptobrevin of Schizosaccharomyces pombe. Syb1 was located on various sizes of vesicle-like structures in the cytoplasm and enriched in the medial region and cell ends. Transport of Syb1 to the medial region was mainly dependent on F-actin and Myo52/Myo4. Syb1 is essential for cell viability and most of the syb1-null cells showed a round or short cylindrical form. These results suggest that Syb1 is involved in membrane trafficking of cytokinesis and cell elongation. (C) 2003 Elsevier Science (USA). All rights reserved.
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页码:641 / 645
页数:5
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