Pharmacokinetics of moxidectin in alpacas following administration of an oral or subcutaneous formulation

The purpose of this study was to evaluate the pharmacokinetics of moxidectin in alpacas after single subcutaneous injection of a non-aqueous formulation or oral administration of an aqueous drench at 0.2 mg.kg(-1). Plasma moxidectin concentrations were measured with reverse phase HPLC, and data analyzed using non compartmental methods. Half-life was longer (p = 0.02) after subcutaneous administration than oral (292 +/- 170 vs 33 +/- 39 h). The area under the concentration-time curve was greater (p = 0.04) following subcutaneous administration (1484.8 +/- 1049.5 h. ng*ml(-1)) than oral (157.6 +/- 85.9 h*ng*ml(-1)). The peak concentration (C-max) was higher and the after subcutaneous administration, but the difference was not statistically significant (p = 0.18). The relative bioavailability of the oral moxidectin to the subcutaneous moxidectin was 11%. The data suggest a higher relative bioavailability following subcutaneous compared to oral administration. Further studies are needed to determine the therapeutic concentrations of moxidectin in alpacas. (C) 2016 Elsevier Ltd. All rights reserved.