Effect of Gastric Bypass Surgery on the Oxidative Stress Status in Morbidly Obese Patients

In recent years, morbid obesity cases have increased. Inflammation and oxidative stress levels are also elevated in these people, and many obesity-related diseases arise from high levels of these factors in obesity. Therefore, in the present study, the effect of gastric bypass surgery on the oxidative and antioxidant status of morbidly obese people was investigated. This prospective cohort study was performed on 35 patients aged between 18 and 54 years old (25 women and 10 men) with morbid obesity (average body mass index: 42.06 kg/m2). Plasma levels of total antioxidant capacity, total oxidant status, reduced glutathione, malondialdehyde, C-reactive protein, and biochemical factors were measured 1 day before and 4 months after surgery. Results of the study showed a significant reduction in anthropometric measurements (body mass index, hip and waist circumference, and waist-to-hip ratio) 4 months after surgery. The lipid profile of the study participants was improved significantly after surgery. Also, serum levels of inflammatory markers and C-reactive protein were decreased (p = 0.003) after surgery. Levels of oxidative stress indicators including total antioxidant capacity, total oxidant status, and malondialdehyde were significantly reduced after surgery. However, serum level of reduced glutathione showed a significant increase after surgery (p = 0.005). According to the findings of our study, in individuals suffering from morbid obesity, levels of oxidative stress and inflammation were decreased after surgery, and weight loss indicated the important role of adipose tissue in the induction of oxidative stress and inflammatory factors.