Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRIE)

被引：160
作者：
Horiuchi, Kumiko
Shiota, Sumiko
Hatano, Tsutomu
Yoshida, Takashi
Kuroda, Teruo
Tsuchiya, Tomofusa [1 ]
机构：
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Microbiol, Okayama 7008530, Japan
[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pharmacognosy, Okayama 7008530, Japan
[3] Shujitsu Univ, Sch Pharm, Dept Biol Pharm, Lab Pathogen Microbiol, Okayama 7038516, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2007年 / 30卷 / 06期
关键词：
oleanolic acid; ursolic acid; vancomycin-resistant enterococci (VRE); bactericidal activity; Sage;
D O I：
10.1248/bpb.30.1147
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
An extract from Salvia officinalis (Sage) leaves showed antimicrobial activity against vancomycin-resistant enterococci (VRE). We isolated the effective compound and identified it as oleanolic acid, a triterpenoid. We also tested antimicrobial activity of similar triterpenoids, ursolic acid, uvaol, betulinic acid and betulin. We found that ursolic acid also showed antimicrobial activity against VRE. The minimum inhibitory concentrations (MICs) of oleanolic acid and ursolic acid were 8 and 4 mu g/ml, respectively. These two compounds also showed antimicrobial activity against Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). These compounds showed bactericidal activity against VRE at least for 48 h when added at concentrations that were two-times higher than their MICs.
引用
收藏
页码：1147 / 1149
页数：3
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