Binding of poly(amidoamine), carbosilane, phosphorus and hybrid dendrimers to thrombin-Constants and mechanisms

被引：8
|
作者：
Shcharbin, Dzmitry [1 ]
Pedziwiatr-Werbicka, Elzbieta [2 ]
Vcherashniaya, Aliaksandra [3 ]
Janaszewska, Anna [2 ]
Marcinkowska, Monika [2 ]
Goska, Piotr [2 ]
Klajnert-Maculewicz, Barbara [2 ]
Ionov, Maksim [2 ]
Abashkin, Viktar [1 ]
Ihnatsyeu-Kachan, Aliaksei [1 ]
Javier de la Mata, F. [4 ,5 ]
Ortega, Paula [4 ,5 ]
Gomez-Ramirez, Rafael [4 ,5 ]
Majoral, Jean-Pierre [6 ]
Bryszewska, Maria [2 ]
机构：
[1] Inst Biophys & Cell Engn NASB, Minsk, BELARUS
[2] Univ Lodz, Fac Biol & Environm Protect, Dept Gen Biophys, Lodz, Poland
[3] Belarusian State Univ, Dept Biophys, Fac Phys, Minsk, BELARUS
[4] Univ Alcala, Dept Quim Organ & Quim Inorgan, Alcala De Henares, Spain
[5] Networking Res Ctr Bioengn Biomat & Nanomed CIBER, Zaragoza, Spain
[6] CNRS, Lab Chim Coordinat, Toulouse, France
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2017年 / 155卷
关键词：
Dendrimer; Thrombin; Interactions; Mechanisms; NANOMEDICINE;
D O I：
10.1016/j.colsurfb.2017.03.053
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Thrombin is an essential part of the blood coagulation system; it is a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, and catalyzes many other coagulation-related reactions. Absorption at its surface of small nanoparticles can completely change the biological properties of thrombin. We have analyzed the influence on thrombin of 3 different kinds of small nanoparticles: dendrimers (phosphorus-based, carbosilane based and polyamidoamine) and 2 hybrid systems containing carbosilane, viologen and phosphorus dendritic scaffolds in one single molecule, bearing different flexibility, size and surface charge. There was significant alteration in the rigidity of the rigid dendrimers in contrast to flexible dendrimers. These differences in their action are important in understanding interactions taking place at a bio-nanointerface. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：11 / 16
页数：6
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