Microenvironmental regulation of Notch signalling in T cell development

被引：29

作者：

Harman, BC ^{[1
]}

Jenkinson, EJ ^{[1
]}

Anderson, G ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, MRC, Dept Anat,Ctr Immune Regulat,Div Immun & Infect, Birmingham B15 2TT, W Midlands, England

来源：

SEMINARS IN IMMUNOLOGY | 2003年 / 15卷 / 02期

基金：

英国医学研究理事会;

关键词：

microenvironment; Notch; T cell development; lymphoid progenitor;

D O I：

10.1016/S1044-5323(03)00005-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cells develop in the thymus from blood-borne progenitors derived from haematopoietic tissues. Amongst the mechanisms by which stromal cells in thymic and prethymic tissues influence lymphoid progenitors, recent attention has focussed on the importance of Notch signalling in early T cell development. Here, we review evidence that developing T cells and their progenitors receive signals through Notch receptors as a result of interactions with Notch ligands expressed by stromal cells. In particular, we focus on the role of Notch ligand-expressing stromal cells in regulating key control points during pre- and intrathymic phases of T cell development. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：91 / 97

页数：7

共 59 条

[1] Notch signaling in hematopoiesis and early lymphocyte development [J].