IgM in human immunity to Plasmodium falciparum malaria

被引：86

作者：

Boyle, M. J. ^{[1
,2
,3
,21
]}

Chan, J. A. ^{[1
]}

Handayuni, I. ^{[2
]}

Reiling, L. ^{[1
]}

Feng, G. ^{[1
,4
]}

Hilton, A. ^{[1
]}

Kurtovic, L. ^{[1
,5
]}

Oyong, D. ^{[2
,6
]}

Piera, K. A. ^{[2
]}

Barber, B. E. ^{[2
,3
,7
]}

William, T. ^{[7
,8
]}

Eisen, D. P. ^{[9
]}

Minigo, G. ^{[2
,6
]}

Langer, C. ^{[1
]}

Drew, D. R. ^{[1
]}

Rivera, F. de Labastida ^{[3
]}

Amante, F. H. ^{[3
]}

Williams, T. N. ^{[10
,11
]}

Kinyanjui, S. ^{[10
,12
]}

Marsh, K. ^{[10
,12
]}

Doolan, D. L. ^{[9
]}

Engwerda, C. ^{[3
]}

Fowkes, F. J. I. ^{[1
,13
,14
]}

Grigg, M. J. ^{[2
,7
]}

Mueller, I. ^{[15
,16
,17
]}

McCarthy, J. S. ^{[3
,18
]}

Anstey, N. M. ^{[2
,6
]}

Beeson, J. G. ^{[1
,4
,19
,20
]}

机构：

[1] Burnet Inst Med Res & Publ Hlth, Melbourne, Vic, Australia

[2] Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia

[3] QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia

[4] Univ Melbourne, Dept Med, Melbourne, Vic, Australia

[5] Monash Univ, Dept Immunol & Pathol, Melbourne, Vic, Australia

[6] Charles Darwin Univ, Darwin, NT, Australia

[7] Queen Elizabeth Hosp, Infect Dis Soc, Sabah Menzies Sch Hlth Res, Clin Res Unit, Kota Kinabalu, Sabah, Malaysia

[8] Gleneagles Hosp, Kota Kinabalu, Sabah, Malaysia

[9] James Cook Univ, Australian Inst Trop Hlth & Med, Cairns, Qld, Australia

[10] KEMRI Wellcome Trust Res Programme, Kenya Med Res Inst KEMRI, Ctr Geog Med, Kilifi, Kenya

[11] Imperial Coll, London, England

[12] Univ Oxford, Nuffield Dept Med, Oxford, England

[13] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia

[14] Monash Univ, Dept Infect Dis, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia

[15] Walter & Eliza Hall Inst Med Res, Melbourne, Vic, Australia

[16] Univ Melbourne, Dept Med Biol, Melbourne, Vic, Australia

[17] Inst Pasteur, Dept Parasites & Insect Vectors, Paris, France

[18] Univ Queensland, Brisbane, Qld, Australia

[19] Monash Univ, Dept Microbiol, Melbourne, Vic, Australia

[20] Monash Univ, Cent Clin Sch, Melbourne, Vic, Australia

[21] QIMR Berghofer Med Res Inst, Herston, Qld 4006, Australia

来源：

SCIENCE ADVANCES | 2019年 / 5卷 / 09期

基金：

澳大利亚国家健康与医学研究理事会; 英国惠康基金; 澳大利亚研究理事会; 英国医学研究理事会;

关键词：

MEROZOITE SURFACE-PROTEINS; IMMUNOGLOBULIN-M; COMPLEMENT; ANTIBODIES; INVASION; PROTECTION; BINDING; INFECTION; KNOWLESI; DISEASE;

D O I：

10.1126/sciadv.aax4489

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to assess the dynamics of malaria-specific IgM during experimentally induced and naturally acquired malaria, we identified IgM activity against blood-stage parasites. We found that merozoite-specific IgM appears rapidly in Plasmodium falciparum infection and is prominent during malaria in children and adults with lifetime exposure, together with IgG. Unexpectedly, IgM persisted for extended periods of time; we found no difference in decay of merozoite-specific IgM over time compared to that of IgG. IgM blocked merozoite invasion of red blood cells in a complement-dependent manner. IgM was also associated with significantly reduced risk of clinical malaria in a longitudinal cohort of children. These findings suggest that merozoite-specific IgM is an important functional and long-lived antibody response targeting blood-stage malaria parasites that contributes to malaria immunity.

引用

页数：14

共 38 条

[1] Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas [J].

Adu, Bright ;

Cherif, Mariama K. ;

Bosomprah, Samuel ;

Diarra, Amidou ;

Arthur, Fareed K. N. ;

Dickson, Emmanuel K. ;

Corradin, Giampietro ;

Cavanagh, David R. ;

Theisen, Michael ;

Sirima, Sodiomon B. ;

Nebie, Issa ;

Dodoo, Daniel .

MALARIA JOURNAL, 2016, 15

[2] Pharmacokinetics of total immunoglobulin G and immunoglobulin G subclasses in patients undergoing replacement therapy for primary immunodeficiency syndromes [J].

Alyanakian, MA ;

Bernatowska, E ;

Scherrmann, JM ;

Aucouturier, P ;

Poplavsky, JL .

VOX SANGUINIS, 2003, 84 (03) :188-192

[3] A Prospective Comparative Study of Knowlesi, Falciparum, and Vivax Malaria in Sabah, Malaysia: High Proportion With Severe Disease From Plasmodium Knowlesi and Plasmodium Vivax But No Mortality With Early Referral and Artesunate Therapy [J].

Barber, Bridget E. ;

William, Timothy ;

Grigg, Matthew J. ;

Menon, Jayaram ;

Auburn, Sarah ;

Marfurt, Jutta ;

Anstey, Nicholas M. ;

Yeo, Tsin W. .

CLINICAL INFECTIOUS DISEASES, 2013, 56 (03) :383-397

[4] Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria [J].

Beeson, James G. ;

Drew, Damien R. ;

Boyle, Michelle J. ;

Feng, Gaoqian ;

Fowkes, Freya J. I. ;

Richards, Jack S. .

FEMS MICROBIOLOGY REVIEWS, 2016, 40 (03) :343-372

[5] Human Antibodies Fix Complement to Inhibit Plasmodium falciparum Invasion of Erythrocytes and Are Associated with Protection against Malaria [J].

Boyle, Michelle J. ;

Reiling, Linda ;

Feng, Gaoqian ;

Langer, Christine ;

Osier, Faith H. ;

Aspeling-Jones, Harvey ;

Cheng, Yik Sheng ;

Stubbs, Janine ;

Tetteh, Kevin K. A. ;

Conway, David J. ;

McCarthy, James S. ;

Muller, Ivo ;

Marsh, Kevin ;

Anders, Robin F. ;

Beeson, James G. .

IMMUNITY, 2015, 42 (03) :580-590

[6] Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development [J].

Boyle, Michelle J. ;

Wilson, Danny W. ;

Richards, Jack S. ;

Riglar, David T. ;

Tetteh, Kevin K. A. ;

Conway, David J. ;

Ralph, Stuart A. ;

Baum, Jake ;

Beeson, James G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (32) :14378-14383

[7] CELLULAR MECHANISMS INVOLVED IN RECOVERY FROM ACUTE MALARIA IN GAMBIAN CHILDREN [J].

BROWN, J ;

GREENWOOD, BM ;

TERRY, RJ .

PARASITE IMMUNOLOGY, 1986, 8 (06) :551-564

[8] Dichotomous miR expression and immune responses following primary blood-stage malaria [J].

Burel, Julie G. ;

Apte, Simon H. ;

Groves, Penny L. ;

Boyle, Michelle J. ;

Langer, Christine ;

Beeson, James G. ;

McCarthy, James S. ;

Doolan, Denise L. .

JCI INSIGHT, 2017, 2 (15)

[9] Virus and antibody dynamics in acute West Nile virus infection [J].

Busch, Michael P. ;

Kleinman, Steven H. ;

Tobler, Leslie H. ;

Kamel, Hany T. ;

Norris, Philip J. ;

Walsh, Irina ;

Matud, Jose L. ;

Prince, Harry E. ;

Lanciotti, Robert S. ;

Wright, David J. ;

Linnen, Jeffrey M. ;

Caglioti, Sally .

JOURNAL OF INFECTIOUS DISEASES, 2008, 198 (07) :984-993

[10] THE CLASSICAL COMPLEMENT PATHWAY - ACTIVATION AND REGULATION OF THE 1ST COMPLEMENT COMPONENT [J].

COOPER, NR .

ADVANCES IN IMMUNOLOGY, 1985, 37 :151-216

← 1 2 3 4 →