Antiradical Activity of Porphyrins with a Diisobornylphenol Fragment at the Macrocycle Periphery

被引：7

作者：

Belykh, Dmitrii V. ^{[1
]}

Mazaletskaya, Lidiya I. ^{[2
]}

Sheludchenko, Nataliya I. ^{[2
]}

Rocheva, Tatyana K. ^{[1
]}

Khudyaeva, Irina S. ^{[1
]}

Buravlev, Evgeny V. ^{[1
]}

Shchukina, Olga V. ^{[1
]}

Chukicheva, Irina Yu. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Chem, Ural Branch, Komi Sci Ctr, 48 Ul Pervomayskaya, Syktyvkar 167000, Russia

[2] Russian Acad Sci, Emanuel Inst Biochem Phys, 4 Ul Kosygina, Moscow 119334, Russia

来源：

MOLECULES | 2018年 / 23卷 / 07期

基金：

俄罗斯科学基金会;

关键词：

tetra(meso-aryl)porphyrins; chlorophyll derivatives; 2; 6-diisobornylphenol; antiradical activity; stoichiometric inhibition coefficient; inhibited ethylbenzene oxidation; ASYMMETRICALLY SUBSTITUTED TETRA(MESO-ARYL)PORPHYRINS; ANTIOXIDANT ACTIVITY; CHLORIN; ISOBORNYLPHENOLS; PHENOL;

D O I：

10.3390/molecules23071718

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article focuses on the antiradical activity of a number of 2,6-diisobornylphenol-porphyrin conjugates with various spacers between the porphyrin and phenolic fragments in the model reaction of ethylbenzene oxidation initiated by azoisobutyric acid dinitrile. The study has shown that the electronic effects of the groups directly related to the 2,6-diisobornylphenol fragment exert the predominant influence both on the reactivity of the phenolic hydroxyl group in interaction with free radicals and on the antiradical activity of the molecule as a whole. The antiradical activity of the molecule is generally less affected by the nature of the substituents in the porphyrin macrocycle, mainly due to a change in the stoichiometric inhibition coefficient in the presence of relatively easily oxidizable groups. It was found that the length of the spacer between the porphyrin and phenolic fragments does not affect the antiradical activity of the conjugate.

引用

页数：10

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