Antioxidant and antiviral activities of silybin fatty acid conjugates

被引：54

作者：

Gazak, Radek ^{[1
]}

Purchartova, Katerina ^{[1
]}

Marhol, Petr ^{[1
]}

Zivna, Lucie ^{[1
]}

Sedmera, Petr ^{[1
]}

Valentova, Katerina ^{[2
]}

Kato, Nobuo ^{[3
]}

Matsumura, Hiroyo ^{[3
]}

Kaihatsu, Kunihiro ^{[3
]}

Kren, Vladimir ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Microbiol, CZ-14220 Prague, Czech Republic

[2] Palacky Univ, Dept Med Chem & Biochem, Fac Med & Dent, CZ-77515 Olomouc, Czech Republic

[3] Osaka Univ, Inst Sci & Ind Res, Dept Organ Fine Chem, Osaka 5670047, Japan

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 03期

关键词：

Silybin; Silibinin; Influenza virus; Lipophilic derivatives; Lipid peroxidation; Antiviral; LIPID-PEROXIDATION; PHOSPHATIDYLCHOLINE COMPLEX; PHOSPHOLIPID COMPLEX; VITAMIN-E; SILYMARIN; DERIVATIVES; INHIBITION; MECHANISM; SILIPIDE; MARIANUM;

D O I：

10.1016/j.ejmech.2009.11.056

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were tested for their antioxidant (inhibition of lipid peroxidation and DPPH-scavenging) and anti-influenza virus activities. The acyl chain length is an important prerequisite for both biological activities, as they improved with increasing length of the acyl moiety. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：1059 / 1067

页数：9

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