Second Meeting of the French CEIP (Centres d'Evaluation et d'Information sur la Pharmacodependance). Part II: Benzodiazepine Withdrawal

被引：2

作者：

Authier, Nicolas ^{[1
,2
]}

Boucher, Alexandra ^{[3
]}

Lamaison, Dominique ^{[1
]}

Llorca, Pierre-Michel

Descotes, Jacques ^{[3
]}

Eschalier, Alain ^{[1
,2
]}

机构：

[1] CHU Clermont Ferrand, CEIP assoc, Clermont Ferrand, France

[2] Fac Med, INSERM, UMR 766, Clermont Ferrand, France

[3] CEIP, Lyon, France

来源：

THERAPIE | 2009年 / 64卷 / 06期

关键词：

benzodiazepines; addiction; abuse; withdrawal; PSYCHOTROPIC-DRUG USE; GENERAL-POPULATION; ABUSE; NEUROENDOCRINE; DEPENDENCE; THERAPY; FRANCE;

D O I：

10.2515/therapie/2009051

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this meeting was to describe the news trends about abuse and addiction of anxiolytics and hypnotics. The part II of this meeting reviewed several aspects of the withdrawing benzodiazepines focusing in particular on clinical symptoms, biological patterns, and strategies for disconstinuation. The discontinuation is usually beneficial due to the importance of adverse effects induced by long-terme use of benzodiazepines. Several clinicals options have been described including gradual tapering of the current benzodiazepine, substitution with a long acting benzodiazepines or treating the symptoms of withdrawal. Psychological interventions range from a simple support through counselling to expert cognitive-behavioural therapy. However more controlled clinical trials are needed to promote adequate and optimal patient care in management of benzodiazepine withdrawing.

引用

页码：365 / 370

页数：6

共 33 条

[1]

Alonso J, 2004, ACTA PSYCHIAT SCAND, V109, P55

[2] The diagnosis and management of benzodiazepine dependence [J].

Ashton, H .

CURRENT OPINION IN PSYCHIATRY, 2005, 18 (03) :249-255

[3]

Ashton H., 2002, BENZODIAZEPINE ABUSE, P197

[4]

AUTHIER N, 2009, ANN PHARM IN PRESS

[5] Opioid and benzodiazepine withdrawal syndromes in the paediatric intensive care unit: a review of recent literature [J].

Birchley, Giles .

NURSING IN CRITICAL CARE, 2009, 14 (01) :26-37

[6]

BLIN O, 2008, ENCEPHALE, V34, P3

[7] Increased AMPA Receptor GluR1 Subunit Incorporation in Rat Hippocampal CA1 Synapses During Benzodiazepine Withdrawal [J].

Das, Paromita ;

Lilly, Scott M. ;

Zerda, Ricardo ;

Gunning, William T., III ;

Alvarez, Francisco J. ;

Tietz, Elizabeth I. .

JOURNAL OF COMPARATIVE NEUROLOGY, 2008, 511 (06) :832-846

[8]

Denis C., 2006, COCHRANE DB SYST REV, V3, P1

[9]

Gasquet I, 2005, ENCEPHALE, V31, P195

[10] Psychotropic drug use and correspondence with psychiatric diagnoses in the mental health in the general population survey [J].

Grolleau, A. ;

Cougnard, A. ;

Begaud, B. ;

Verdoux, H. .

ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE, 2008, 34 (04) :352-359

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