The Predictive Value of Lp(a) for Adverse Cardiovascular Event in ACS Patients With an Achieved LDL-C Target at Follow Up After PCI

被引：15

作者：

Ren, Yongkui ^{[1
]}

Pan, Weili ^{[1
]}

Li, Xinsheng ^{[1
]}

Wang, Shuai ^{[1
]}

Lv, Haichen ^{[1
]}

Yu, Yao ^{[1
]}

Wang, Minxian ^{[1
]}

Xia, Yunlong ^{[1
]}

Yin, Da ^{[1
]}

机构：

[1] Dalian Med Univ, Affiliated Hosp 1, Dept Cardiol, Dalian, Peoples R China

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2022年 / 15卷 / 01期

关键词：

Low-density lipoprotein cholesterol; Lipoprotein(a); Major adverse cardiovascular events; LIPOPROTEIN(A) LEVELS; FUTURE CORONARY; HEART-DISEASE; RISK; ASSOCIATION; CHOLESTEROL; EVOLOCUMAB; GUIDELINES; MANAGEMENT;

D O I：

10.1007/s12265-021-10148-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Low-density lipoprotein cholesterol (LDL-C) is a traditional and important risk factor for atherosclerotic cardiovascular disease (CVD). Recently, lipoprotein (a) (lp(a)) attracts considerable attention as a residual risk factor for CVD. However, the roles of lp(a) in acute coronary syndrome (ACS) patients with well-controlled LDL-C (<= 1.8mmol/L) after percutaneous coronary intervention (PCI) remain unclear. Current study results demonstrated that occurrence of major adverse cardiovascular events (MACE) and recurrent myocardial infarction (MI) increased with the Lp(a) increasing in patients with LDL-C <= 1.8mmol/L at 1-month follow-up. In relatively low-risk patients presented with ACS and underwent PCI (LDL-C <= 1.8mmol/L at 1-month follow-up), lp(a) is still independently related to adverse prognosis. Further researches of targeted therapy against lp(a) are warranted.

引用

页码：67 / 74

页数：8

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