Polyploidy, Aneuploidy and the Evolution of Cancer

被引：0

作者：

Merlo, Lauren M. F. ^{[1
]}

Wang, Li-san ^{[6
,7
]}

Pepper, John W. ^{[5
]}

Rabinovitch, Peter S. ^{[2
,3
,4
]}

Maley, Carlo C. ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Mol & Cellular Oncogenesis Program, Philadelphia, PA 19104 USA

[2] Univ Washington, Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98195 USA

[3] Univ Washington, Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98195 USA

[4] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[5] Univ Arizona, Dept Ecol & Evolut Biol, Tucson, AZ 85721 USA

[6] Univ Penn, Dept Pathol & Lab Med, Penn Ctr Bioinformat, Philadelphia, PA 19104 USA

[7] Univ Penn, Penn Ctr Bioinformat, Inst Aging, Philadelphia, PA 19104 USA

来源：

POLYPLOIDIZATION AND CANCER | 2010年 / 676卷

关键词：

COMPARATIVE GENOMIC HYBRIDIZATION; CYTOMETRIC DNA ANALYSIS; BARRETTS-ESOPHAGUS; STEM-CELLS; COLORECTAL-CANCER; PANCREATIC-CANCER; PROSPECTIVE IDENTIFICATION; NEOPLASTIC PROGRESSION; ESCHERICHIA-COLI; MYELOID-LEUKEMIA;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aneuploidy is a ubiquitous feature of cancer and pre-cancerous lesions, yet its significance is poorly characterized. In this chapter, we review the role of tetraploidy and aneuploidy in progression. We examine how aneuploidy may contribute to the evolutionary dynamics prevalent in neoplastic progression, considering whether aneuploidy itself is selectively neutral or advantageous or if it simply acts as a mechanism for the more rapid accumulation of mutations increasing survival and reproduction of cancer cells. We also review evidence from Barrett's esophagus, a pre-malignant condition, demonstrating that tetraploidy and aneuploidy are correlated with an increased risk of progression to cancer. Ultimately, we aim provide testable hypotheses and methods for understanding the role of aneuploidy in cancer.

引用

页码：1 / 13

页数：13

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