Various immunostaining patterns of CD31, CD34 and endoglin and their relationship with lymph node metastasis in oral squamous cell carcinomas

被引：44

作者：

Nagatsuka, H

Hibi, K

Gunduz, M

Tsujigiwa, H

Tamamura, R

Sugahara, T

Sasaki, A

Nagai, N

机构：

[1] Okayama Univ, Grad Sch Med & Dent, Dept Oral Med & Pathol, Okayama 7008525, Japan

[2] Okayama Univ, Grad Sch Med & Dent, Dept Oral & Maxillofacial Reconstruct Surg, Okayama 7008525, Japan

[3] Okayama Univ, Grad Sch Med & Dent, Dept Oral & Maxillofacial Surg& Biopathol, Okayama 7008525, Japan

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2005年 / 34卷 / 02期

关键词：

angiogenesis; CD31; CD34; endoglin; oral cancer;

D O I：

10.1111/j.1600-0714.2004.00227.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

BACKGROUND: Intratumoral blood vessels are known to play an important role in cancer growth and metastasis. The discrepancy in previous reports using various endothelial markers individually suggested us to investigate both normal and various tumor areas with a wide panel of vascular markers. METHODS: Here, we used a panel of three antibodies (CD31, CD34, and endoglin) as blood vessel markers to investigate the distribution and properties of blood vessels in normal oral tissues and squamous cell carcinomas. RESULTS: Many microvessels with strong remodeling activity as well as undifferentiated tumoral vascular endothelial cells and immature endothelial cells were present in the cancer cell nest and marginal area of cancer infiltration. Our results showed different vascular distribution patterns using various immunostaining markers in normal and tumoral tissues. CONCLUSION: Vascular distribution and properties of endothelial cells appear to be closely associated with metastasis.

引用

页码：70 / 76

页数：7

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