Acetylcarnitine Is a Candidate Diagnostic and Prognostic Biomarker of Hepatocellular Carcinoma

被引：84
作者：
Lu, Yonghai [1 ]
Li, Ning [2 ]
Gao, Liang [3 ]
Xu, Yong-Jiang [4 ]
Huang, Chong [2 ]
Yu, Kangkang [2 ]
Ling, Qingxia [2 ]
Cheng, Qi [2 ]
Chen, Shengsen [2 ]
Zhu, Mengqi [2 ]
Fang, Jinling [1 ]
Chen, Mingquan [2 ]
Ong, Choon Nam [1 ,3 ]
机构：
[1] Natl Univ Singapore, Sch Publ Hlth, Singapore 117549, Singapore
[2] Fudan Univ, Huashan Hosp, Dept Infect Dis & Hepatol, 12 Wulumuqi Zhong Rd, Shanghai 200040, Peoples R China
[3] Natl Univ Singapore, NUS Environm Res Inst, Singapore 117548, Singapore
[4] Chinese Acad Sci, Key Lab Insect Dev & Evolutionary Biol, Inst Plant Physiol & Ecol, Shanghai Inst Biol Sci, Shanghai, Peoples R China
来源：
CANCER RESEARCH | 2016年 / 76卷 / 10期
关键词：
LARGE-SCALE; CARNITINE LEVELS; GENE-EXPRESSION; METABOLOMICS; CANCER; IDENTIFICATION; METABOLISM; DISCOVERY; OXIDATION; CIRRHOSIS;
D O I：
10.1158/0008-5472.CAN-15-3199
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The identification of serum biomarkers to improve the diagnosis and prognosis of hepatocellular carcinoma has been elusive to date. In this study, we took a mass spectroscopic approach to characterize metabolic features of the liver in hepatocellular carcinoma patients to discover more sensitive and specific biomarkers for diagnosis and progression. Global metabolic profiling of 50 pairs of matched liver tissue samples from hepatocellular carcinoma patients was performed. A series of 62 metabolites were found to be altered significantly in liver tumors; however, levels of acetylcarnitine correlated most strongly with tumor grade and could discriminate between hepatocellular carcinoma tumors and matched normal tissues. Post hoc analysis to evaluate serum diagnosis and progression potential further confirmed the diagnostic capability of serum acetylcarnitine. Finally, an external validation in an independent batch of 58 serum samples (18 hepatocellular carcinoma patients, 20 liver cirrhosis patients, and 20 healthy individuals) verified that serum acetylcarnitine was a meaningful biomarker reflecting hepatocellular carcinoma diagnosis and progression. These findings present a strong new candidate biomarker for hepatocellular carcinoma with potentially significant diagnostic and prognostic capabilities. (C) 2016 AACR.
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收藏
页码：2912 / 2920
页数：9
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