T-Follicular-Like CD8+ T Cell Responses in Chronic HIV Infection Are Associated With Virus Control and Antibody Isotype Switching to IgG

被引：3

作者：

Romero-Martin, Luis ^{[1
,2
]}

Tarres-Freixas, Ferran ^{[1
]}

Pedreno-Lopez, Nuria ^{[1
]}

de la Concepcion, Maria L. Rodriguez ^{[1
]}

Cunyat, Francesc ^{[1
]}

Hartigan-O'Connor, Dennis ^{[3
,4
,5
]}

Carrillo, Jorge ^{[1
,6
]}

Mothe, Beatriz ^{[1
,6
,7
,8
]}

Blanco, Julia ^{[1
,6
,7
]}

Ruiz-Riol, Marta ^{[1
,6
]}

Brander, Christian ^{[1
,6
,9
,10
]}

Olvera, Alex ^{[1
,6
,7
]}

机构：

[1] Hosp Germans Trias i Pujol, IrsiCaixa AIDS Res Inst, Inst Hlth Sci Res Germans Trias i Pujol IGTP, Badalona, Spain

[2] Univ Autonoma Barcelona, Dept Biol Cellular Fisiol & Immunol, Cerdanyola Del Valles, Spain

[3] Univ Calif Davis, Dept Med Microbiol & Immunol, Davis, CA USA

[4] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA USA

[5] Univ Calif San Francisco, Div Expt Med, San Francisco, CA USA

[6] Inst salud Carlos III, Ctr Invest Biomed Red, CIBERINFEC, Madrid, Spain

[7] Univ Vic, Cent Univ Catalonia, Vic, Spain

[8] Hosp Univ Germans Trias i Pujol, Infect Dis Dept, Fdn Lluita Sida, Badalona, Spain

[9] Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain

[10] AELIX Therapeut, Barcelona, Spain

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

基金：

欧盟地平线“2020”;

关键词：

HIV; humoral immune response; human immunodeficiency virus (HIV) control; T-follicular cytotoxic (Tfc) cells; viral control; TFH CELLS; HETEROGENEITY; CD4; NEUTRALIZATION; INDIVIDUALS; PHENOTYPE; ASSAY; GAG;

D O I：

10.3389/fimmu.2022.928039

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cell responses are considered critical for the in vivo control of HIV, but the contribution of different T cell subsets to this control remains unclear. Using a boosted flow cytometric approach that is able to differentiate CD4(+) and CD8(+) T cell Th1/Tc1, Th2/Tc2, Th17/Tc17, Treg and Tfh/Tfc-like HIV-specific T cell populations, we identified CD8(+) Tfc responses that were related to HIV plasma viral loads and associated with rate of antibody isotype class switching to IgG. This favorable balance towards IgG responses positively correlated with increased virus neutralization, higher avidity of neutralizing antibodies and more potent antibody-dependent cell cytotoxicity (ADCC) in PBMCs from HIV controllers compared to non-controllers. Our results identified the CD8(+) Tfc-like T-cell response as a component of effective virus control which could possibly be exploited therapeutically.

引用

页数：17

共 75 条

[1] Nef-Specific CD8+T Cell Responses Contribute to HIV-1 Immune Control [J].