Protection of the abnormal heart

被引：13
作者：
Pantos, Constantinos
Mourouzis, Iordanis
Cokkinos, Dennis V.
机构：
[1] Univ Athens, Dept Pharmacol, Athens 11527, Greece
[2] Onassis Cardiac Surg Ctr, Dept Cardiol 1, Athens 17674, Greece
来源：
HEART FAILURE REVIEWS | 2007年 / 12卷 / 3-4期
关键词：
ischemia; preconditioning; hypertrophy; diabetes; thyroxine; heart failure; aging;
D O I：
10.1007/s10741-007-9036-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Myocardial ischemia and reperfusion injury have been extensively investigated in the laboratory mainly in healthy tissues. However, in clinical settings, ischemic heart disease coexists with certain illnesses, which could potentially influence the response of the myocardium to ischemia and reperfusion. Recent research has revealed that the abnormal heart may not be always vulnerable to ischemic injury. Furthermore, the effect of powerful means of protection, such as ischemic preconditioning, may not be in operation under certain pathological conditions. With this evidence in mind, the present review will focus on the response of the abnormal heart to ischemia and reperfusion, the possible underlying mechanisms, and potential cardioprotective strategies.
引用
收藏
页码：319 / 330
页数：12
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