Coordination metal complexes with Schiff bases: Useful pharmacophores with comprehensive biological applications

被引：122
作者：
Ghanghas, Priyanka [1 ]
Choudhary, Anita [1 ]
Kumar, Dinesh [2 ]
Poonia, Kavita [1 ]
机构：
[1] Banasthali Vidyapith, Dept Chem, Tonk 304022, India
[2] Cent Univ Gujarat, Sch Chem Sci, Gandhinagar 382030, India
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2021年 / 130卷
关键词：
Schiff base; Metal complexes; Antimicrobial activities; Antioxidant activities; DNA interactions; Anticancer activities; DNA-BINDING; STRUCTURAL-CHARACTERIZATION; SPECTRAL CHARACTERIZATION; ANTIMICROBIAL ACTIVITY; SPECTROSCOPIC CHARACTERIZATION; THIOSEMICARBAZONE COMPLEXES; CRYSTAL-STRUCTURE; CO(II) COMPLEXES; ANTIBACTERIAL EVALUATION; HOMOBINUCLEAR COMPLEXES;
D O I：
10.1016/j.inoche.2021.108710
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Antibiotic-resistant infections on the health care system and the population have put a burden on economic and adequate health. There is an urgent need to develop new synthetic moieties with a better and acceptable therapeutic index. Schiff bases and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compounds. Schiff bases metal complexes are proven as potential candidates who show effective activity towards anti-inflammatory, antifungal, antibacterial, antiproliferative, antimalarial, antipyretic, antiviral properties etc. The occurrence of basic donor N, S and O atoms in the skeleton of the Schiff base makes them well-suited ligands in coordinating chemistry. They are found to be a versatile pharmacophore for designing and developing many bioactive lead compounds. This review begins with a brief introduction to Schiff bases and their complexes. It summarizes the various biological activities (antimicrobial activities, antioxidant activities, DNA interactions, anticancer activities) delivered by Schiff base metal complexes. It also highlights the recent advancement in the field of Schiff base coordination chemistry and its future prospects as a potential bioactive core.
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页数：29
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共 134 条
[11]  
Abid K., 2016, American Journal of Chemistry, V6, P1, DOI DOI 10.3390/APP6020040
[12]  
Abid K.K., 2016, J. Am. Chem. Soc, V6, P29
[13]   Spectroscopic and structural studies of the Schiff base 3-methoxy-N-salicylidene-o-amino phenol complexes with some transition metal ions and their antibacterial, antifungal activities [J].
Abo-Aly, M. M. ;
Salem, A. M. ;
Sayed, M. A. ;
Aziz, A. A. Abdel .
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2015, 136 :993-1000
[14]   Targeting ctDNA binding and elaborated in-vitro assessments concerning novel Schiff base complexes: Synthesis, characterization, DFT and detailed in-silico confirmation [J].
Abu-Dief, Ahmed M. ;
El-Metwaly, Nashwa M. ;
Alzahrani, Seraj Omar ;
Bawazeer, Afrah M. ;
Shaaban, Saad ;
Adam, Mohamed Shaker S. .
JOURNAL OF MOLECULAR LIQUIDS, 2021, 322 (322)
[15]   A robust in vitro Anticancer, Antioxidant and Antimicrobial Agents Based on New Metal-Azomethine Chelates Incorporating Ag(I), Pd (II) and VO (II) Cations: Probing the Aspects of DNA Interaction [J].
Abu-Dief, Ahmed M. ;
Abdel-Rahman, Laila H. ;
Abdel-Mawgoud, Azza A. Hassan .
APPLIED ORGANOMETALLIC CHEMISTRY, 2020, 34 (02)
[16]   Novel azomethine Pd (II)- and VO (II)-based metallo-pharmaceuticals as anticancer, antimicrobial, and antioxidant agents: Design, structural inspection, DFT investigation, and DNA interaction [J].
Abu-Dief, Ahmed M. ;
Abdel-Rahman, Laila H. ;
Shehata, Mohamed R. ;
Abdel-Mawgoud, Azza A. Hassan .
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 2019, 32 (12)
[17]   Fabrication, spectroscopic characterization, calf thymus DNA binding investigation, antioxidant and anticancer activities of some antibiotic azomethine Cu(II), Pd(II), Zn(II) and Cr(III) complexes [J].
Abu-Dief, Ahmed M. ;
El-Sagher, Hussein M. ;
Shehata, Mohamed R. .
APPLIED ORGANOMETALLIC CHEMISTRY, 2019, 33 (08)
[18]   Tailoring, physicochemical characterization, antibacterial and DNA binding mode studies of Cu(II) Schiff bases amino acid bioactive agents incorporating 5-bromo-2-hydroxybenzaldehyde [J].
Abu-Dief, Ahmed M. ;
Nassr, Lobna A. E. .
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2015, 12 (06) :943-955
[19]   Tailoring, structural inspection of novel oxy and non-oxy metal-imine chelates for DNA interaction, pharmaceutical and molecular docking studies [J].
Adam, Mohamed Shaker S. ;
Abu-Dief, Ahmed M. ;
Makhlouf, M. M. ;
Shaaban, Saad ;
Alzahrani, Seraj O. ;
Alkhatib, Fatmah ;
Masaret, Ghada S. ;
Mohamed, Mamdouh A. ;
Alsehli, Mosa ;
El-Metwaly, Nashwa M. ;
Mohamad, Ahmad Desoky M. .
POLYHEDRON, 2021, 201
[20]   Synthesis, catalysis, antimicrobial activity, and DNA interactions of new Cu(II)-Schiff base complexes [J].
Adam, Mohamed Shaker S. ;
Abdel-Rahman, Laila H. ;
Abu-Dief, Ahmed M. ;
Hashem, Nahla A. .
INORGANIC AND NANO-METAL CHEMISTRY, 2020, 50 (03) :136-150
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