Nonylphenol causes decrease in antioxidant enzyme activities, increase in O2-content, and alteration in ultrastructures of FG cells, a flounder (Paralichthys olivaceus) gill cell line

被引：22

作者：

Xiao, Qin ^{[1
]}

Zhang, Shicui ^{[1
]}

Guo, Huarong ^{[1
]}

Su, Feng ^{[1
]}

Xu, Yuyan ^{[1
]}

机构：

[1] Ocean Univ China, Dept Marine Biol, Qingdao 266003, Peoples R China

来源：

TOXICOLOGY MECHANISMS AND METHODS | 2007年 / 17卷 / 03期

关键词：

antioxidant enzymes; cell culture; flounder; nonylphenol; superoxide anion; ATP content; ultrastructure;

D O I：

10.1080/15376510600860227

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The findings in this study were that the exposure of FG cells to nonylphenol (NP) caused decreases in the cell growth rate, antioxidant enzyme activities, and ATP content; an increase in intracellular O-2(-) content; and alteration of the organelles such as mitochondria and the RER. It is proposed that the reduction in antioxidant enzyme activities leads to accumulation of O-2(-) content, which in turn results in the damage of mitochondrial infrastructures and a decline in energy production, which then causes the ultrastructural alterations in the cells. In addition, we show that FG cells are a good candidate system for evaluation of NP acute toxicities.

引用

页码：127 / 134

页数：8

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