Patients with hematologic cancers are more vulnerable to COVID-19 compared to patients with solid cancers

被引：14

作者：

Basci, Semih ^{[1
,2
]}

Ata, Naim ^{[3
]}

Altuntas, Fevzi ^{[1
,2
,4
]}

Yigenoglu, Tugce Nur ^{[1
,2
]}

Dal, Mehmet Sinan ^{[1
,2
]}

Korkmaz, Serdal ^{[5
]}

Namdaroglu, Sinem ^{[6
]}

Basturk, Abdulkadir ^{[7
]}

Hacibekiroglu, Tuba ^{[8
]}

Dogu, Mehmet Hilmi ^{[9
]}

Berber, Ilhami ^{[10
]}

Dal, Kursat ^{[11
]}

Erkurt, Mehmet Ali ^{[10
]}

Turgut, Burhan ^{[12
]}

Celik, Osman ^{[13
]}

Ulgu, Mustafa Mahir ^{[14
]}

Birinci, Suayip ^{[15
]}

机构：

[1] Univ Hlth Sci, Ankara Oncol Training & Res Hosp, Dept Hematol, Ankara, Turkey

[2] Univ Hlth Sci, Ankara Oncol Training & Res Hosp, Bone Marrow Transplantat Ctr, Ankara, Turkey

[3] Minist Hlth, Dept Strategy Dev, Ankara, Turkey

[4] Ankara Yildirim Beyazit Univ, Sch Med, Dept Hematol, Ankara, Turkey

[5] Kayseri City Hosp, Dept Hematol, Kayseri, Turkey

[6] Bozyaka Training & Res Hosp, Dept Hematol, Izmir, Turkey

[7] Selcuk Univ, Sch Med, Dept Hematol, Konya, Turkey

[8] Sakarya Univ, Sch Med, Dept Hematol, Sakarya, Turkey

[9] Istanbul Training & Res Hosp, Dept Hematol, Istanbul, Turkey

[10] Inonu Univ, Sch Med, Dept Hematol, Malatya, Turkey

[11] Kecioren Training & Res Hosp, Dept Internal Med, Ankara, Turkey

[12] Namik Kemal Univ, Sch Med, Dept Hematol, Tekirdag, Turkey

[13] Minist Hlth, Publ Hosp Gen Directorate, Ankara, Turkey

[14] Minist Hlth, Gen Directorate Hlth Informat Syst, Ankara, Turkey

[15] Minister Hlth, Ankara, Turkey

来源：

INTERNAL AND EMERGENCY MEDICINE | 2022年 / 17卷 / 01期

关键词：

COVID-19; SARS-CoV-2; Hematologic cancer; Solid tumor;

D O I：

10.1007/s11739-021-02784-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Previous studies reported that COVID-19 patients with cancer had higher rates of severe events such as intensive care unit (ICU) admission, mechanical ventilation (MV) assistance, and death during the COVID-19 course compared to the general population. However, no randomized study compared the clinical course of COVID-19 in patients with hematologic cancers to patients with solid cancers. Thus, in this study, we intend to reveal the outcome of COVID-19 in hematologic cancer patients and compare their outcomes with COVID-19 patients with solid cancers. The data of 926 laboratory-confirmed COVID-19 patients, including 463 hematologic cancer patients and an age-gender paired cohort of 463 solid cancer patients, were investigated retrospectively. The frequencies of severe and critical disease, hospital and ICU admission, MV assistance were significantly higher in hematologic cancer patients compared with the solid cancer patients (p = 0.001, p = 0.045, p = 0.001, and p = 0.001, respectively). The hospital stay was longer in patients with hematologic cancers (p = 0.001); however, the median ICU stay was 6 days in both groups. The case fatality rate (CFR) was 14.9% in patients with hematologic cancers, and it was 4.8% in patients with solid cancers, and there was a statistically significant difference regarding CFR between groups (p = 0.001). Our study revealed that COVID-19 patients with hematologic cancers have a more aggressive course of COVID-19 and have higher CFR compared to COVID-19 patients with solid cancers and support the increased susceptibility of patients with hematologic cancers during the outbreak.

引用

页码：135 / 139

页数：5

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