The design, synthesis and Anti-HIV activity of a selected group of 2′,3′-didehydro-2′,3′-dideoxyguanosine (d4G) and 2′,3′-dideoxyguanosine (ddG) 'ProTide' derivatives

被引:0
|
作者
Mehellou, Youcef
McGuigan, Christopher
Balzarini, Jan
机构
[1] Univ Cardiff Wales, Welsh Sch Pharm, Cardiff, S Glam, Wales
[2] Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium
关键词
D O I
10.1016/j.antiviral.2007.01.063
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
55
引用
收藏
页码:A50 / A50
页数:1
相关论文
共 50 条
  • [21] THE USE OF ACETYL BROMIDE FOR THE MULTIGRAM SYNTHESIS OF THE ANTI-HIV AGENT 2',3'-DIDEHYDRO-2',3'-DIDEOXYCYTIDINE (D4C)
    STARRETT, JE
    TORTOLANI, DR
    BAKER, DC
    OMAR, MT
    HEBBLER, AK
    WOS, JA
    MARTIN, JC
    MANSURI, MM
    NUCLEOSIDES & NUCLEOTIDES, 1990, 9 (07): : 885 - 897
  • [22] Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3′-azido-2′,3′-dideoxythymidine and 2′,3′-didehydro-2′,3′-dideoxythymidine
    Cardona, VMF
    Ayi, AI
    Aubertin, AM
    Guedj, R
    ANTIVIRAL RESEARCH, 1999, 42 (03) : 189 - 196
  • [23] THE ANTI-HTLV-III (ANTI-HIV) AND CYTOTOXIC ACTIVITY OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYRIBONUCLEOSIDES - A COMPARISON WITH THEIR PARENTAL 2',3'-DIDEOXYRIBONUCLEOSIDES
    BALZARINI, J
    KANG, GJ
    DALAL, M
    HERDEWIJN, P
    DECLERCQ, E
    BRODER, S
    JOHNS, DG
    MOLECULAR PHARMACOLOGY, 1987, 32 (01) : 162 - 167
  • [24] Improved and reliable synthesis of 3′-azido-2′,3′-dideoxyguanosine derivatives
    Timoshchuk, VA
    Hogrefe, RI
    Vaghefi, MM
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2004, 23 (1-2): : 171 - 181
  • [25] PHOSPHONATE ISOSTERES OF 2',3'-DIDEHYDRO-2,3-DIDEOXYNUCLEOSIDE MONOPHOSPHATES - SYNTHESIS AND ANTI-HIV ACTIVITY
    KIM, CU
    LUH, BY
    MISCO, PF
    MARTIN, JC
    NUCLEOSIDES & NUCLEOTIDES, 1991, 10 (1-3): : 371 - 375
  • [26] Synthesis and anti-HIV activity of 4′-cyano-2′,3′-didehydro-3′-deoxythymidine
    Haraguchi, K
    Itoh, Y
    Takeda, S
    Honma, Y
    Tanaka, H
    Nitanda, T
    Baba, M
    Dutschman, GE
    Cheng, YC
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2004, 23 (04): : 647 - 654
  • [27] DNA CHAIN TERMINATION ACTIVITY AND INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS REVERSE-TRANSCRIPTASE BY CARBOCYCLIC 2',3'-DIDEHYDRO-2',3'-DIDEOXYGUANOSINE TRIPHOSPHATE
    ORR, DC
    FIGUEIREDO, HT
    MO, CL
    PENN, CR
    CAMERON, JM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1992, 267 (06) : 4177 - 4182
  • [28] D- and L-2′,3′-didehydro-2′,3′-dideoxy-3′-fluoro-carbocyclic nucleosides:: Synthesis, anti-HIV activity and mechanism of resistance
    Wang, Jianing
    Jin, Yunho
    Rapp, Kimberly L.
    Schinazi, Raymond F.
    Chu, Chung K.
    JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (08) : 1828 - 1839
  • [29] L-2′,3′-Didehydro-2′,3′-dideoxy-3′-fluoronucleosides:: Synthesis, anti-HIV activity, chemical and enzymatic stability, and mechanism of resistance
    Chong, Y
    Gumina, G
    Mathew, JS
    Schinazi, RF
    Chu, CK
    JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (15) : 3245 - 3256
  • [30] Synthesis, anti-HIV activity, and molecular mechanism of drug resistance of L-2',3′-didehydro-2′,3′-dideoxy-2′-fluoro-4′-thionucleosides
    Choo, H
    Chong, YH
    Choi, YS
    Mathew, J
    Schinazi, RF
    Chu, CK
    JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (03) : 389 - 398