PET Imaging of 18F-FDG, 11C-methionine, 11C-flumazenil, and 11C-4DST in Progressive Multifocal Leukoencephalopathy

被引：8

作者：

Ishibashi, Kenji ^{[1
,2
]}

Miura, Yoshiharu ^{[2
]}

Matsumura, Ken ^{[2
]}

Kanemasa, Yusuke ^{[3
]}

Nakamichi, Kazuo ^{[4
]}

Saijo, Masayuki ^{[4
]}

Toyohara, Jun ^{[1
]}

Ishii, Kenji ^{[1
]}

机构：

[1] Tokyo Metropolitan Inst Gerontol, Res Team Neuroimaging, Tokyo, Japan

[2] Tokyo Metropolitan Canc & Infect Dis Ctr Komagome, Dept Neurol, Tokyo, Japan

[3] Tokyo Metropolitan Canc & Infect Dis Ctr Komagome, Dept Med Oncol, Tokyo, Japan

[4] Natl Inst Infect Dis, Dept Virol 1, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2017年 / 56卷 / 10期

关键词：

progressive multifocal leukoencephalopathy; positron emission tomography; F-18-FDG; C-11-methionine; C-11-flumazenil; C-11-4DST; JC VIRUS; INFECTION; PML;

D O I：

10.2169/internalmedicine.56.8080

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The use of positron emission tomography (PET) imaging in progressive multifocal leukoencephalopathy (PML) has rarely been reported. We herein report a set of PET images in a 63-year-old patient with PML. In PML lesions, the uptake of F-18-fluorodeoxyglucose, C-11-methionine, C-11-flumazenil, and [methyl-C-11] 4 '-thiothymidine was decreased, increased, decreased, and unchanged, respectively. These results suggest that glucose metabolism decreased, protein synthesis increased, neuronal integrity decreased, and the DNA synthesis and cellular proliferation of host cells were not activated in PML lesions. These results may reflect very little infiltration by inflammatory cells and active infection with JC virus in this case.

引用

页码：1219 / 1223

页数：5

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