The Role of Double-Strand Break Repair Pathways at Functional and Dysfunctional Telomeres

被引:90
作者
Doksani, Ylli [1 ]
de lange, Titia [1 ]
机构
[1] Rockefeller Univ, Lab Cell Biol & Genet, New York, NY 10065 USA
基金
美国国家卫生研究院;
关键词
DNA-DAMAGE-RESPONSE; HUMAN-CELLS; HOMOLOGOUS RECOMBINATION; END RESECTION; MAMMALIAN TELOMERES; PROTECTS TELOMERES; HOLLIDAY JUNCTIONS; CHROMOSOME ENDS; REPLICATION; TRF2;
D O I
10.1101/cshperspect.a016576
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Telomeres have evolved to protect the ends of linear chromosomes from the myriad of threats posed by the cellular DNA damage signaling and repair pathways. Mammalian telomeres have to block nonhomologous end joining (NHEJ), thus preventing chromosome fusions; they need to control homologous recombination (HR), which could change telomere lengths; they have to avoid activating the ATM (ataxia telangiectasia mutated) and ATR (ATM- and RAD3-related) kinase pathways, which could induce cell cycle arrest; and they have to protect chromosome ends from hyperresection. Recent studies of telomeres have provided insights into the mechanisms of NHEJ and HR, how these double-strand break (DSB) repair pathways can be thwarted, and how telomeres have co-opted DNA repair factors to help in the protection of chromosome ends. These aspects of telomere biology are reviewed here with particular emphasis on recombination, the main focus of this collection.
引用
收藏
页数:15
相关论文
共 110 条
[21]   Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells [J].
Conomos, Dimitri ;
Stutz, Michael D. ;
Hills, Mark ;
Neumann, Axel A. ;
Bryan, Tracy M. ;
Reddel, Roger R. ;
Pickett, Hilda A. .
JOURNAL OF CELL BIOLOGY, 2012, 199 (06) :893-906
[22]   Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protection [J].
Dai, Xueyu ;
Huang, Chenhui ;
Bhusari, Amruta ;
Sampathi, Shilpa ;
Schubert, Kathryn ;
Chai, Weihang .
EMBO JOURNAL, 2010, 29 (16) :2788-2801
[23]   How Telomeres Solve the End-Protection Problem [J].
de Lange, Titia .
SCIENCE, 2009, 326 (5955) :948-952
[24]   Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching [J].
Di Virgilio, Michela ;
Callen, Elsa ;
Yamane, Arito ;
Zhang, Wenzhu ;
Jankovic, Mila ;
Gitlin, Alexander D. ;
Feldhahn, Niklas ;
Resch, Wolfgang ;
Oliveira, Thiago Y. ;
Chait, Brian T. ;
Nussenzweig, Andre ;
Casellas, Rafael ;
Robbiani, Davide F. ;
Nussenzweig, Michel C. .
SCIENCE, 2013, 339 (6120) :711-715
[25]   Cell Cycle-Dependent Role of MRN at Dysfunctional Telomeres: ATM Signaling-Dependent Induction of Nonhomologous End Joining (NHEJ) in G1 and Resection-Mediated Inhibition of NHEJ in G2 [J].
Dimitrova, Nadya ;
de Lange, Titia .
MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (20) :5552-5563
[26]   Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation [J].
Doksani, Ylli ;
Wu, John Y. ;
de Lange, Titia ;
Zhuang, Xiaowei .
CELL, 2013, 155 (02) :345-356
[27]   Break-induced replication occurs by conservative DNA synthesis [J].
Donnianni, Roberto A. ;
Symington, Lorraine S. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (33) :13475-13480
[28]   Telomere maintenance by recombination in human cells [J].
Dunham, MA ;
Neumann, AA ;
Fasching, CL ;
Reddel, RR .
NATURE GENETICS, 2000, 26 (04) :447-450
[29]   A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice [J].
Escribano-Diaz, Cristina ;
Orthwein, Alexandre ;
Fradet-Turcotte, Amelie ;
Xing, Mengtan ;
Young, Jordan T. F. ;
Tkac, Jan ;
Cook, Michael A. ;
Rosebrock, Adam P. ;
Munro, Meagan ;
Canny, Marella D. ;
Xu, Dongyi ;
Durocher, Daniel .
MOLECULAR CELL, 2013, 49 (05) :872-883
[30]   RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair [J].
Feng, Lin ;
Fong, Ka-Wing ;
Wang, Jiadong ;
Wang, Wenqi ;
Chen, Junjie .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (16) :11135-11143