Agmatine-Containing Poly(amidoamine)s as a Novel Class of Antiviral Macromolecules: Structural Properties and In Vitro Evaluation of Infectivity Inhibition

被引：22

作者：

Donalisio, Manuela ^{[1
]}

Ranucci, Elisabetta ^{[2
]}

Cagno, Valeria ^{[1
]}

Civra, Andrea ^{[1
]}

Manfredi, Amedea ^{[2
]}

Cavalli, Roberta ^{[3
]}

Ferruti, Paolo ^{[2
]}

Lembo, David ^{[1
]}

机构：

[1] Univ Turin, Dipartimento Sci Clin & Biol, Turin, Italy

[2] Univ Milan, Dipartimento Chim Organ & Ind, Milan, Italy

[3] Univ Turin, Dipartimento Sci & Tecnol Farm, Turin, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 10期

关键词：

SULFATE-BINDING PEPTIDE; HEPARAN-SULFATE; ENDOSOMOLYTIC POLYMERS; HUMAN CYTOMEGALOVIRUS; HUMAN-PAPILLOMAVIRUS; VIRUS INFECTIVITY; PROTEOGLYCANS; PROTEIN; CELLS;

D O I：

10.1128/AAC.03420-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Poly(amidoamine)s (PAAs) are multifunctional tert-amine polymers endowed with high structural versatility. Here we report on the screening of a minilibrary of PAAs against a panel of viruses. The PAA AGMA1 showed antiviral activity against herpes simplex virus, human cytomegalovirus, human papillomavirus 16, and respiratory syncytial virus but not against human rotavirus and vesicular stomatitis virus. The results suggest the contribution of both a polycationic nature and side guanidine groups in imparting antiviral activity.

引用

页码：6315 / 6319

页数：5

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