Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival

被引：215
作者：
Hock, H
Meade, E
Medeiros, S
Schindler, JW
Valk, PJM
Fujiwara, Y
Orkin, SH [1 ]
机构：
[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Childrens Hosp,Div Hematol Oncol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
[4] Howard Hughes Med Inst, Boston, MA 02115 USA
来源：
GENES & DEVELOPMENT | 2004年 / 18卷 / 19期
关键词：
Ets; hematopoietic stem cell; megakarvocyte; Cre/loxP; Tel/Etv6;
D O I：
10.1101/gad.1239604
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Hematopoietic stem cells (HSCs) sustain blood formation throughout life. Pathways regulating maintenance of adult HSCs are largely unknown. Here we report that the Ets-related transcription factor Tel/Etv6, the product of a locus frequently involved in translocations in leukemia, is a selective regulator of HSC survival. Following inactivation of Tel/Etv6, HSCs are lost in the adult bone marrow but their progeny are unaffected and transiently sustain blood formation. Accordingly, absence of Tel/Etv6 after lineage commitment is ostensibly without consequence except for unexpected impairment of maturation of megakaryocytes. Thus, we establish Tel/Etv6 as a selective and essential regulator of postembryonic HSCs.
引用
收藏
页码：2336 / 2341
页数：6
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