Pneumococcal pneumonia infection is associated with end-stage renal disease in adult hospitalized patients

被引：28

作者：

Huang, Shih-Ting ^{[1
,2
]}

Lin, Cheng-Li ^{[3
]}

Chang, Yen-Jung ^{[4
]}

Sher, Yuh-Pyng ^{[5
,6
]}

Wu, Ming-Ju ^{[1
]}

Shu, Kuo-Hsiung ^{[1
]}

Sung, Fung-Chang ^{[2
,3
]}

Kao, Chia-Hung ^{[2
,7
,8
,9
]}

机构：

[1] Taichung Vet Gen Hosp, Div Nephrol, Dept Med, Taichung, Taiwan

[2] China Med Univ, Coll Med, Sch Med, Grad Inst Clin Med Sci, Taichung 404, Taiwan

[3] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan

[4] Natl Taiwan Normal Univ, Dept Hlth Promot & Hlth Educ, Taipei, Taiwan

[5] China Med Univ, Grad Inst Canc Biol, Taichung 404, Taiwan

[6] China Med Univ, Ctr Mol Med, Taichung 404, Taiwan

[7] China Med Univ, Sch Med, Taichung 404, Taiwan

[8] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan

[9] China Med Univ Hosp, PET Ctr, Taichung, Taiwan

来源：

KIDNEY INTERNATIONAL | 2014年 / 86卷 / 05期

关键词：

community-acquired pneumonia; hemolytic uremic syndrome; inflammation; renal failure; Streptococcus pneumoniae; vaccine; HEMOLYTIC-UREMIC SYNDROME; NECROSIS-FACTOR-ALPHA; COMMUNITY-ACQUIRED PNEUMONIA; CHRONIC KIDNEY-DISEASE; UROKINASE RECEPTOR; HEART-FAILURE; RISK-FACTORS; PROGRESSION; VALIDATION; MECHANISMS;

D O I：

10.1038/ki.2014.79

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Pneumococcal disease leads to renal complications ranging from persistent proteinuria to end-stage renal disease (ESRD) in pediatric patients. However, long-term renal effects after pneumococcal pneumonia infection in adult patients remains largely unknown. To evaluate this we conducted a population-based retrospective cohort study consisting of 18,733 adult patients at the time of pneumococcal pneumonia diagnosis, using claims data from Taiwan's National Health Insurance Research Database (NHIRD) with a comparison cohort of 73,409 age- and gender-matched patients without pneumococcal pneumonia. The overall incidence rate ratio of ESRD was 23% higher in those with pneumococcal pneumonia than in those without pneumococcal pneumonia (5.26 vs. 3.10 per 1000 person-years), with an adjusted hazard ratio of 1.14 (95% confidence interval 1.01-1.29). In addition, the risk of developing ESRD was associated with covariates including age, gender, chronic kidney disease, diabetes mellitus, hypertension, hyperlipidemia, chronic obstructive pulmonary disease, and heart failure. The ESRD cumulative incidence curve showed a considerably higher risk of ESRD in those with pneumococcal pneumonia than in those without pneumococcal pneumonia (significant by log-rank test). Thus, pneumococcal pneumonia may be associated with an increased risk of ESRD in adult patients. A long-term follow-up of renal function is recommended for adult hospitalized patients with pneumococcal pneumonia infection.

引用

页码：1023 / 1030

页数：8

共 44 条

[1]

[Anonymous], 2009, Six Countries, Six Reform Models: their Healthcare Reform: Experience of Israel, the Netherlands

[2]

[Anonymous], 2012, USRDS 2012 ANN DAT R

[3] Review of pneumococcal endocarditis in adults in the penicillin era [J].