Homeostasis and Inflammation in the Intestine

被引：628
作者：
Garrett, Wendy S. [1 ,2 ]
Gordon, Jeffrey I. [3 ]
Glimcher, Laurie H. [1 ,2 ,4 ]
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
[3] Washington Univ, Sch Med, Ctr Genome Sci, St Louis, MO 63108 USA
[4] Massachusetts Gen Hosp East, Ragon Inst MGH Harvard MIT, Boston, MA 02129 USA
来源：
CELL | 2010年 / 140卷 / 06期
基金：
美国国家卫生研究院;
关键词：
EPITHELIAL TIGHT JUNCTIONS; GENOME-WIDE ASSOCIATION; T-BET DEFICIENCY; DENDRITIC CELLS; CROHNS-DISEASE; STROMAL CELLS; ENTEROENDOCRINE CELLS; GERM-FREE; ADAPTIVE IMMUNITY; INNATE IMMUNITY;
D O I：
10.1016/j.cell.2010.01.023
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The gut is home to our largest collection of microbes. The ability of the immune system to coevolve with the microbiota during postnatal life allows the host and microbiota to coexist in a mutually beneficial relationship. Failure to achieve or maintain equilibrium between a host and its microbiota has negative consequences for both intestinal and systemic health. In this Review, we consider the many cellular and molecular methods by which inflammatory responses are regulated to maintain intestinal homeostasis and the disease states that can ensue when this balance is lost.
引用
收藏
页码：859 / 870
页数：12
相关论文
共 122 条
[1]   Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses [J].
Amit, Ido ;
Garber, Manuel ;
Chevrier, Nicolas ;
Leite, Ana Paula ;
Donner, Yoni ;
Eisenhaure, Thomas ;
Guttman, Mitchell ;
Grenier, Jennifer K. ;
Li, Weibo ;
Zuk, Or ;
Schubert, Lisa A. ;
Birditt, Brian ;
Shay, Tal ;
Goren, Alon ;
Zhang, Xiaolan ;
Smith, Zachary ;
Deering, Raquel ;
McDonald, Rebecca C. ;
Cabili, Moran ;
Bernstein, Bradley E. ;
Rinn, John L. ;
Meissner, Alex ;
Root, David E. ;
Hacohen, Nir ;
Regev, Aviv .
SCIENCE, 2009, 326 (5950) :257-263
[2]   The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs [J].
Androulidaki, Ariadne ;
Iliopoulos, Dimitrios ;
Arranz, Alicia ;
Doxaki, Christina ;
Schworer, Steffen ;
Zacharioudaki, Vassiliki ;
Margioris, Andrew N. ;
Tsichlis, Philip N. ;
Tsatsanis, Christos .
IMMUNITY, 2009, 31 (02) :220-231
[3]   Junctional Adhesion Molecule-A Is Required for Hematogenous Dissemination of Reovirus [J].
Antar, Annukka A. R. ;
Konopka, Jennifer L. ;
Campbell, Jacquelyn A. ;
Henry, Rachel A. ;
Perdigoto, Ana L. ;
Carter, Bruce D. ;
Pozzi, Ambra ;
Abel, Ty W. ;
Dermody, Terence S. .
CELL HOST & MICROBE, 2009, 5 (01) :59-71
[4]   ATP drives lamina propria TH17 cell differentiation [J].
Atarashi, Koji ;
Nishimura, Junichi ;
Shima, Tatsuichiro ;
Umesaki, Yoshinori ;
Yamamoto, Masahiro ;
Onoue, Masaharu ;
Yagita, Hideo ;
Ishii, Naoto ;
Evans, Richard ;
Honda, Kenya ;
Takeda, Kiyoshi .
NATURE, 2008, 455 (7214) :808-U10
[5]   Hybrid Treg cells: steel frames and plastic exteriors [J].
Barnes, Michael J. ;
Powrie, Fiona .
NATURE IMMUNOLOGY, 2009, 10 (06) :563-564
[6]   A cell biological view of Toll-like receptor function: regulation through compartmentalization [J].
Barton, Gregory M. ;
Kagan, Jonathan C. .
NATURE REVIEWS IMMUNOLOGY, 2009, 9 (08) :535-542
[7]   Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota [J].
Bates, Jennifer M. ;
Akerlund, Janie ;
Mittge, Erika ;
Guillemin, Karen .
CELL HOST & MICROBE, 2007, 2 (06) :371-382
[8]   Regulatory T Cells in the Control of Host-Microorganism Interactions [J].
Belkaid, Yasmine ;
Tarbell, Kristin .
ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :551-589
[9]   Gut Commensal Bacteria Direct a Protective Immune Response against Toxoplasma gondii [J].
Benson, Alicia ;
Pifer, Reed ;
Behrendt, Cassie L. ;
Hooper, Lora V. ;
Yarovinsky, Felix .
CELL HOST & MICROBE, 2009, 6 (02) :187-196
[10]   Intercellular Junctional Proteins as Receptors and Barriers to Virus Infection and Spread [J].
Bergelson, Jeffrey M. .
CELL HOST & MICROBE, 2009, 5 (06) :517-521
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