Calcium Handling and Arrhythmogenesis

被引：3

作者：

Bompotis, Georgios C. ^{[1
]}

Pappas, Loukas K. ^{[2
,3
]}

Angelidis, Christos ^{[2
,3
]}

Kossyvakis, Charalampos ^{[2
,3
]}

Giannopoulos, Georgios ^{[4
]}

Deftereos, Spyridon ^{[4
]}

机构：

[1] Papageorgiou Hosp, Dept Cardiol 2, Thessaloniki, Greece

[2] Athens Gen Hosp G Gennimatas, Dept Cardiol, Athens, Greece

[3] Athens Gen Hosp G Gennimatas, Cardiac Catheterizat Lab, Athens, Greece

[4] Yale Univ, Sch Med, Dept Internal Med, Sect Cardiovasc Med, New Haven, CT 06510 USA

来源：

MEDICINAL CHEMISTRY | 2016年 / 12卷 / 02期

关键词：

Calcium; arrhythmia; pathophysiology; pathogenesis; POLYMORPHIC VENTRICULAR-TACHYCARDIA; CA2+/CALMODULIN-DEPENDENT PROTEIN-KINASE; RETICULUM CA2+ LEAK; RYANODINE RECEPTOR PHOSPHORYLATION; SARCOPLASMIC-RETICULUM; NA+-CA2+ EXCHANGER; EARLY AFTERDEPOLARIZATIONS; ATRIAL-FIBRILLATION; HEART-FAILURE; CONTRACTILE DYSFUNCTION;

D O I：

10.2174/157340641202160209102839

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Intracellular calcium homeostasis plays a fundamental role in the electric and mechanical function of the heart by modulating action potential pattern and duration, by linking cell membrane depolarization to myocardial contraction and by regulating cardiac automaticity. Abnormalities of intracellular calcium regulation disrupt the electrophysiological properties of the heart and create an arrhythmogenic milieu, which promotes atrial and ventricular arrhythmogenesis and impairs cardiac automaticity and atrioventricular conduction. In this brief review, we summarize the basic genetic, molecular and electrophysiological mechanisms linking inherited or acquired intracellular Ca2+ dysregulation to arrhythmogenesis.

引用

页码：170 / 176

页数：7

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