The Immunological Synapse

被引：330

作者：

Dustin, Michael L. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Orthoped Rheumatol & Musculoskeleta, Kennedy Inst Rheumatol, Headington OX3 7FY, Oxon, England

来源：

CANCER IMMUNOLOGY RESEARCH | 2014年 / 2卷 / 11期

基金：

英国惠康基金;

关键词：

T-CELL-RECEPTOR; SUPRAMOLECULAR ACTIVATION CLUSTERS; REGULATORY T; PROTEIN-KINASE; DENDRITIC CELLS; ANTIGEN RECEPTOR; ADHESION MOLECULES; PKC-THETA; SIGNAL-TRANSDUCTION; TISSUE DISTRIBUTION;

D O I：

10.1158/2326-6066.CIR-14-0161

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The molecular interactions underlying regulation of the immune response take place in a nanoscale gap between T cells and antigen-presenting cells, termed the immunological synapse. If these interactions are regulated appropriately, the host is defended against a wide range of pathogens and deranged host cells. If these interactions are disregulated, the host is susceptible to pathogens or tumor escape at one extreme and autoimmunity at the other. Strategies targeting the synapse have helped to establish immunotherapy as a mainstream element in cancer treatment. This Masters' primer will cover the basics of the immunological synapse and some of the applications to tumor immunology. (C) 2014 AACR.

引用

收藏

页码：1023 / 1033

页数：11

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