Junctional complexes such as tight junctions, adherens junctions, and desmosomes play crucial roles in the structure and function of epithelial cells. These junctions are involved in increasing cell-cell contact and as well serve as signaling centers regulating multiple functions in epithelial cells. Carcinoma cell lines cultured in the laboratory generally lack junctional complexes. However, studies directed towards understanding the distribution of junctional complexes in human cancer tissues are lacking. In this study, we analyzed by electron microscopy the distribution of junctional complexes in patients diagnosed with renal clear-cell carcinoma. We found that both tight junctions and adherens junctions were drastically reduced in patients with cancer compared to normal tissues. Desmosomes were not detected in normal proximal tubules while distinctly present in cancer tissues. These results suggest that analysis of junctional complexes in human tumors should provide valuable information that might have prognostic and diagnostic value.
机构:
Inst Nacl Canc, Appl Genet Lab, Div Hematol, BR-20230130 Rio De Janeiro, RJ, BrazilInst Nacl Canc, Appl Genet Lab, Div Hematol, BR-20230130 Rio De Janeiro, RJ, Brazil
Vieira de Ribeiro, Ana Julia
Sandim, Vanessa
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Inst Nacl Canc, Appl Genet Lab, Div Hematol, BR-20230130 Rio De Janeiro, RJ, BrazilInst Nacl Canc, Appl Genet Lab, Div Hematol, BR-20230130 Rio De Janeiro, RJ, Brazil
Sandim, Vanessa
Ornellas, Antonio Augusto
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Inst Nacl Canc, Div Urol, BR-20230130 Rio De Janeiro, RJ, Brazil
Hosp Mario Kroeff, Div Urol, Rio De Janeiro, RJ, BrazilInst Nacl Canc, Appl Genet Lab, Div Hematol, BR-20230130 Rio De Janeiro, RJ, Brazil
Ornellas, Antonio Augusto
Reis, Rodrigo Siqueira
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Univ Fed Rio de Janeiro, Inst Chem, Prote Unit, BR-21941 Rio De Janeiro, RJ, BrazilInst Nacl Canc, Appl Genet Lab, Div Hematol, BR-20230130 Rio De Janeiro, RJ, Brazil
Reis, Rodrigo Siqueira
Domont, Gilberto
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Univ Fed Rio de Janeiro, Inst Chem, Prote Unit, BR-21941 Rio De Janeiro, RJ, BrazilInst Nacl Canc, Appl Genet Lab, Div Hematol, BR-20230130 Rio De Janeiro, RJ, Brazil
Domont, Gilberto
Alves, Gilda
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Inst Nacl Canc, Appl Genet Lab, Div Hematol, BR-20230130 Rio De Janeiro, RJ, BrazilInst Nacl Canc, Appl Genet Lab, Div Hematol, BR-20230130 Rio De Janeiro, RJ, Brazil
机构:
Peninsula Med Sch Headquarters, Mol Med Res Grp, Inst Biomed Sci, Plymouth PL6 8BU, Devon, EnglandPeninsula Med Sch Headquarters, Mol Med Res Grp, Inst Biomed Sci, Plymouth PL6 8BU, Devon, England
Page, T
Hodgkinson, AD
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Peninsula Med Sch Headquarters, Mol Med Res Grp, Inst Biomed Sci, Plymouth PL6 8BU, Devon, EnglandPeninsula Med Sch Headquarters, Mol Med Res Grp, Inst Biomed Sci, Plymouth PL6 8BU, Devon, England
Hodgkinson, AD
Ollerenshaw, M
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Peninsula Med Sch Headquarters, Mol Med Res Grp, Inst Biomed Sci, Plymouth PL6 8BU, Devon, EnglandPeninsula Med Sch Headquarters, Mol Med Res Grp, Inst Biomed Sci, Plymouth PL6 8BU, Devon, England
Ollerenshaw, M
Hammonds, JC
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Peninsula Med Sch Headquarters, Mol Med Res Grp, Inst Biomed Sci, Plymouth PL6 8BU, Devon, EnglandPeninsula Med Sch Headquarters, Mol Med Res Grp, Inst Biomed Sci, Plymouth PL6 8BU, Devon, England
Hammonds, JC
Demaine, AG
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Peninsula Med Sch Headquarters, Mol Med Res Grp, Inst Biomed Sci, Plymouth PL6 8BU, Devon, EnglandPeninsula Med Sch Headquarters, Mol Med Res Grp, Inst Biomed Sci, Plymouth PL6 8BU, Devon, England