Renal clear-cell carcinoma: an ultrastructural study on the junctional complexes

被引:0
|
作者
Kim, G
Rajasekaran, SA
Thomas, G
Rosen, EA
Landaw, EM
Shintaku, P
Lassman, C
Said, J
Rajasekaran, AK
机构
[1] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biomath, Los Angeles, CA 90095 USA
关键词
tight junction; desmosome; adherens junction; renal clear-cell carcinoma;
D O I
暂无
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Junctional complexes such as tight junctions, adherens junctions, and desmosomes play crucial roles in the structure and function of epithelial cells. These junctions are involved in increasing cell-cell contact and as well serve as signaling centers regulating multiple functions in epithelial cells. Carcinoma cell lines cultured in the laboratory generally lack junctional complexes. However, studies directed towards understanding the distribution of junctional complexes in human cancer tissues are lacking. In this study, we analyzed by electron microscopy the distribution of junctional complexes in patients diagnosed with renal clear-cell carcinoma. We found that both tight junctions and adherens junctions were drastically reduced in patients with cancer compared to normal tissues. Desmosomes were not detected in normal proximal tubules while distinctly present in cancer tissues. These results suggest that analysis of junctional complexes in human tumors should provide valuable information that might have prognostic and diagnostic value.
引用
收藏
页码:35 / 44
页数:10
相关论文
共 50 条
  • [31] Treating metastatic clear-cell renal cell carcinoma: beyond immunotherapy
    Gianluca Perego
    Paolo Barzaghi
    Ivano Vavassori
    Fausto Petrelli
    Medical Oncology, 2020, 37
  • [32] Clear-cell papillary renal-cell carcinoma: A case report
    Li, Jiting
    Gong, Chen
    Lv, Dihao
    Ding, Mingxia
    ASIAN JOURNAL OF SURGERY, 2024, 47 (10) : 4633 - 4635
  • [33] Differencial proteome of clear-cell renal cell carcinoma (ccRCC) tissues
    Vieira de Ribeiro, Ana Julia
    Sandim, Vanessa
    Ornellas, Antonio Augusto
    Reis, Rodrigo Siqueira
    Domont, Gilberto
    Alves, Gilda
    INTERNATIONAL BRAZ J UROL, 2013, 39 (01): : 83 - 94
  • [34] Glucose transporter polymorphisms are associated with clear-cell renal carcinoma
    Page, T
    Hodgkinson, AD
    Ollerenshaw, M
    Hammonds, JC
    Demaine, AG
    CANCER GENETICS AND CYTOGENETICS, 2005, 163 (02) : 151 - 155
  • [35] SOLITARY THYROID METASTASIS FROM CLEAR-CELL RENAL CARCINOMA
    MADORE, P
    LAN, S
    CANADIAN MEDICAL ASSOCIATION JOURNAL, 1975, 112 (06) : 719 - &
  • [36] Clear-cell carcinoma of the ovary
    Fujiwara, K.
    Shintani, D.
    Nishikawa, T.
    ANNALS OF ONCOLOGY, 2016, 27 : 50 - 52
  • [37] METASTATIC RENAL TUMOR PRESENTING AS OVARIAN CLEAR-CELL CARCINOMA
    SPENCER, JR
    ERIKSEN, B
    GARNETT, JE
    UROLOGY, 1993, 41 (06) : 582 - 584
  • [38] A THYROID METASTASIS REVEALING AN OCCULT RENAL CLEAR-CELL CARCINOMA
    DALFABBRO, S
    MONARI, G
    BARBAZZA, R
    TUMORI, 1987, 73 (02) : 187 - 190
  • [39] CLEAR-CELL CARCINOMA OF ENDOMETRIUM
    KURMAN, RJ
    SCULLY, RE
    LABORATORY INVESTIGATION, 1974, 30 (03) : 380 - 380
  • [40] CLEAR-CELL CARCINOMA OF THE ENDOMETRIUM
    KAY, S
    CANCER, 1957, 10 (01) : 124 - 130