Gold-catalyzed sequential cyclization/rearrangement reaction of O-allyl hydroxamates: atom economical synthesis of 3-hydroxyisoxazoles

被引：19
作者：
Sugita, Shoichi [1 ]
Ueda, Masafumi [1 ]
Doi, Nobuyoshi [1 ]
Takeda, Norihiko [1 ]
Miyata, Okiko [1 ]
机构：
[1] Kobe Pharmaceut Univ, Higashinada Ku, 4-19-1 Motoyamakita, Kobe, Hyogo 6588558, Japan
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 16期
关键词：
3-Hydroxyisoxazole; Gold catalysis; Cyclization; Rearrangement; Atom economy; 3-ISOXAZOLOL GABA(A) ANTAGONISTS; TRISUBSTITUTED ISOXAZOLES; PHARMACOLOGY; INHIBITOR; DISCOVERY; IDENTIFICATION; AGONISTS; ANALOGS; DESIGN; ACID;
D O I：
10.1016/j.tetlet.2016.03.032
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A gold-catalyzed sequential reaction of O-allyl hydroxamates bearing an alkyne moiety has been developed for the preparation of 3-hydroxyisoxazoles and isoxazole-3-ones. Notably, this domino reaction involving cyclization and rearrangement provided facile access to the desired compounds in a highly atom-economical manner. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1786 / 1789
页数：4
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