Development of 68Ga labeled human serum albumin for blood pool imaging: a comparison between two ligands

被引：8
作者：
Jain, Akanksha [1 ,3 ]
Pandey, Usha [1 ,3 ]
Gamre, Naresh [1 ]
Sarma, Haladhar Dev [2 ]
Dash, Ashutosh [1 ,3 ]
机构：
[1] Bhabha Atom Res Ctr, Radiopharmaceut Div, Mumbai 400085, Maharashtra, India
[2] Bhabha Atom Res Ctr, Radiat Biol & Hlth Sci Div, Mumbai 400085, Maharashtra, India
[3] Homi Bhabha Natl Inst, Mumbai 400094, Maharashtra, India
来源：
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2017年 / 313卷 / 03期
关键词：
PET imaging; Blood pool imaging; Human serum albumin; Ga-68; Bifunctional chelators; POSITRON-EMISSION-TOMOGRAPHY; PET;
D O I：
10.1007/s10967-017-5320-0
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
PET based blood pool imaging tracers have tremendous potential for detection of vascular abnormalities. We synthesized Ga-68-1,4,7-triazacyclononane-1,4,7-triacetic acid-human serum albumin (Ga-68-NOTA-HSA) (1a) towards use in blood pool imaging and compared it with Ga-68-1,4,7,10-tetraazacyclo-dodecane-1,4,7,10-tetraacetic acid-HSA (Ga-68-DOTA-HSA) (2a). Both 1a and 2a had similar biodistribution profiles with >= 70% ID/g activity in blood at 2 min p.i. About 50% of initial radioactivity was retained in blood at 2 h p.i. However, the plasma stability of 1a was superior to that of 2a. Results of our study indicate that Ga-68-NOTA-HSA can be further investigated for clinical blood pool imaging applications.
引用
收藏
页码：661 / 668
页数：8
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