A decade of AIRE

被引：139

作者：

Mathis, Diane ^{[1
]}

Benoist, Christophe

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Sect Immunol & Immunogenet,Joslin Diabet Ctr, Boston, MA 02215 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02215 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 08期

关键词：

D O I：

10.1038/nri2136

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 1997, the autoimmune regulator (AIRE) gene was identified as the locus underlying susceptibility to the polyendocrine autoimmune disease known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). In the intervening 10 years, it has become increasingly clear that this rare disorder has provided us with an illuminative window on one of the most fundamental processes of the immune system - the establishment and maintenance of self tolerance.

引用

页码：645 / 650

页数：6

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