Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature

被引：59

作者：

Kessler, Remi A. ^{[1
]}

Garzon-Muvdi, Tomas ^{[1
]}

Yang, Wuyang ^{[1
]}

Weingart, Jon ^{[1
]}

Olivi, Alessandro ^{[2
]}

Huang, Judy ^{[1
]}

Brem, Henry ^{[1
]}

Lim, Michael ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Dept Neurosurg, Baltimore, MD 21205 USA

[2] Policlin Univ A Gemelli, Dept Neurosurg, Rome, Italy

来源：

WORLD NEUROSURGERY | 2017年 / 101卷

关键词：

Anaplastic; Atypical; Meningioma; Metastasis; Resection; MALIGNANT INTRAVENTRICULAR MENINGIOMA; PHASE-II TRIAL; PULMONARY METASTASES; INTRACRANIAL MENINGIOMA; CEREBROSPINAL-FLUID; SURGICAL RESECTION; CRANIAL MENINGIOMA; SPINAL METASTASIS; GRADE-II; RECURRENT;

D O I：

10.1016/j.wneu.2017.01.070

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BACKGROUND: Atypical (World Health Organization grade II) and anaplastic (World Health Organization grade III) meningiomas are rare, accounting for less than 5% of all meningiomas. Histologic grading has a significant impact on prognosis, risk of recurrence, and the need for adjuvant radiation or chemotherapy. Extracranial metastases are even more infrequent and occur in 0.1% of all cases. METHODS: Retrospective chart review of 168 patients with diagnosis of WHO grade II and III meningiomas was performed. Six patients with histologically confirmed metastatic disease were identified. RESULTS: We discuss the clinical, radiologic, and histopathologic clinical course of 6 patients with metastasis to the lung, liver, and spine from all patients with atypical or anaplastic meningioma treated at Johns Hopkins Hospital from 1993 to 2014. CONCLUSIONS: We reviewed the literature pertaining to this phenomenon and subsequently assessed the clinical benefits of adjuvant chemotherapeutic agents in patients with meningioma with metastatic disease.

引用

页码：47 / 56

页数：10

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