Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis

被引：31
|
作者：
Garay, Laura [1 ,2 ]
Gonzalez Deniselle, Maria Claudia [1 ,3 ]
Sitruk-Ware, Regine [4 ]
Guennoun, Rachida [5 ]
Schumacher, Michael [5 ]
De Nicola, Alejandro F. [1 ,2 ]
机构：
[1] Inst Biol & Med Expt, Lab Neuroendocrine Biochem, RA-1428 Buenos Aires, DF, Argentina
[2] Univ Buenos Aires, Fac Med, Dept Human Biochem, RA-1053 Buenos Aires, DF, Argentina
[3] Univ Buenos Aires, Fac Med, Dept Physiol, RA-1053 Buenos Aires, DF, Argentina
[4] Rockefeller Univ, Populat Council, New York, NY 10021 USA
[5] Univ Paris Sud, UMR Inserm 788, Le Kremlin Bicetre, France
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 276卷 / 1-2期
关键词：
Experimental autoimmune encephalomyelitis; Nestorone; Microglia; Behavior; ADULT HIPPOCAMPAL NEUROGENESIS; MULTIPLE-SCLEROSIS; INFLAMMATION ALTERS; CELL-PROLIFERATION; DENTATE GYRUS; BRAIN-INJURY; SPINAL-CORD; MOUSE MODEL; MALE-MICE; NEUROPROTECTION;
D O I：
10.1016/j.jneuroim.2014.08.619
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Progesterone plays a protective role in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Besides spinal cord neuropathology, MS patients present a dysfunctional hippocampus. In this work we studied the therapeutic effects of the progestin Nestorone in the brain of mice with chronic EAE. Nestorone decreased clinical grade and enhanced motor behavior. In addition, it increased cell proliferation and doublecortin positive neuroblasts in the hippocampus, increased GABAergic interneurons and attenuated the number of Iba1 + microglia/macrophages, events possibly linked to enhancement of neurogenesis. Therefore, Nestorone protected against hippocampus abnormalities and improved functional outcomes of EAE mice, suggesting its potential value for MS. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：89 / 97
页数：9
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