Phenolic constituents from the flower buds of Lonicera japonica and their 5-lipoxygenase inhibitory activities

被引：176

作者：

Lee, Eun Ju ^{[1
,2
]}

Kim, Ju Sun ^{[1
,2
]}

Kim, Hyun Pyo ^{[3
]}

Lee, Je-Hyun ^{[4
]}

Kang, Sam Sik ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Inst Nat Prod Res, Seoul 151742, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[3] Kangwon Natl Univ, Coll Pharm, Chunchen 200701, South Korea

[4] Dongguk Univ, Dept Korean Med, Gyeongju Si 780714, Gyeongbuk, South Korea

来源：

FOOD CHEMISTRY | 2010年 / 120卷 / 01期

关键词：

Lonicera japonica; Phenolics; Vanillic acid 4-O-beta-D-(6-O-benzoylglucopyranoside); 5-Lipoxygenase (5-LOX); TRITERPENOID SAPONINS; ANTIINFLAMMATORY ACTIVITY; FLOS-LONICERAE; MAST-CELLS; ACTIVATION; MECHANISM; EXTRACT;

D O I：

10.1016/j.foodchem.2009.09.088

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Thirteen phenolic constituents, luteolin (1), protocatechuic acid (2), caffeic acid (3), flavoyadorinin-B (4), 4,5-dicaffeoylquinic acid (5), luteolin 7-O-beta-D-glucopyranoside (7), 3,5-dicaffeoylquinic acid methyl ester (8), methyl chlorogenate (9), quercetin 3-O-beta-D-glucopyranoside (10), 3,5-dicaffeoylquinic acid (11), rhoifolin (12), chlorogenic acid (13), and a novel phenolic glucoside benzoate. vanillic acid 4-O-beta-D-(6-O-benzoylglucopyranoside) (6), were isolated from the flower buds of Lonicera japonica. Flavoyadorinin-B (4) was isolated for the first time from a Caprifoliaceae plant. The structures of 1-13 were determined on the basis of chemical and spectroscopic evidence. These compounds were screened for their 5-lipoxygenase inhibitory activity. Only luteolin (1) showed significant inhibitory activity against 5-LOX-catalysed leukotriene production. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：134 / 139

页数：6

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