Liver Cancer Stem Cells as an Important Target in Liver Cancer Therapies

被引：16
作者：
Zou, Gang-Ming [1 ]
机构：
[1] Shanghai Jiao Tong Univ, State Key Lab Oncogene & Related Gene, Shanghai Canc Inst, Shanghai 200240, Peoples R China
来源：
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2010年 / 10卷 / 02期
关键词：
CD133; CD44; CD90; IL-6; TGF-beta; HEPATOCELLULAR-CARCINOMA CELLS; HEPATIC PROGENITOR CELLS; STEM/PROGENITOR CELLS; 1A-DEFICIENT MICE; CHEMORESISTANCE; IDENTIFICATION; EXPANSION; BMI1; BETA;
D O I：
10.2174/187152010790909263
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hepatic cancer is one of most common cause of cancer-related death. Hepato-epithelial cancers are believed to originate from the malignant transformation of liver-resident stem/progenitor cells. Liver cancer stem cells have been characterized recently and the phenotype of liver cancer stem cells has been defined as CD133(+) CD44(+) cancer cells. Recently, it has been also demonstrated about the relevance of targeting liver cancer stem cells, due to cancer stem cells are related to cancer metastasis. These advances no doubt to bring the new strategy in liver cancer treatment and control in this disease. This review describes the current status and progress about cancer stem cell research in liver and discuss of the implications of these studies in new liver cancer treatment strategies.
引用
收藏
页码：172 / 175
页数：4
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