Arresting the Inflammatory Drive of Chronic Lymphocytic Leukemia with Ibrutinib

被引：9

作者：

Bachireddy, Pavan ^{[1
,2
,3
,4
]}

Wu, Catherine J. ^{[1
,2
,3
,4
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Broad Inst MIT & Harvard, Cambridge, MA USA

[3] Harvard Univ, Sch Med, Boston, MA USA

[4] Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA

来源：

CLINICAL CANCER RESEARCH | 2016年 / 22卷 / 07期

关键词：

INHIBITOR; THERAPY; CELLS; ITK;

D O I：

10.1158/1078-0432.CCR-15-3106

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The clinical success of agents targeting the B-cell receptor signaling pathway in chronic lymphocytic leukemia (CLL) may also derive from disrupting the CLL microenvironment. Investigation of the immunomodulatory effects of these agents illuminates the unique immunobiology of CLL and highlights potential targets for dismantling the chronic inflammatory drive. (C) 2016 AACR.

引用

页码：1547 / 1549

页数：3

共 12 条

[1] A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease [J].

Bagnara, Davide ;

Kaufman, Matthew S. ;

Calissano, Carlo ;

Marsilio, Sonia ;

Patten, Piers E. M. ;

Simone, Rita ;

Chum, Philip ;

Yan, Xiao-Jie ;

Allen, Steven L. ;

Kolitz, Jonathan E. ;

Baskar, Sivasubramanian ;

Rader, Christoph ;

Mellstedt, Hakan ;

Rabbani, Hodjattallah ;

Lee, Annette ;

Gregersen, Peter K. ;

Rai, Kanti R. ;

Chiorazzi, Nicholas .

BLOOD, 2011, 117 (20) :5463-5472

[2] Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia [J].

Burger, J. A. ;

Tedeschi, A. ;

Barr, P. M. ;

Robak, T. ;

Owen, C. ;

Ghia, P. ;

Bairey, O. ;

Hillmen, P. ;

Bartlett, N. L. ;

Li, J. ;

Simpson, D. ;

Grosicki, S. ;

Devereux, S. ;

McCarthy, H. ;

Coutre, S. ;

Quach, H. ;

Gaidano, G. ;

Maslyak, Z. ;

Stevens, D. A. ;

Janssens, A. ;

Offner, F. ;

Mayer, J. ;

O'Dwyer, M. ;

Hellmann, A. ;

Schuh, A. ;

Siddiqi, T. ;

Polliack, A. ;

Tam, C. S. ;

Suri, D. ;

Cheng, M. ;

Clow, F. ;

Styles, L. ;

James, D. F. ;

Kipps, T. J. ;

Keating, Michael ;

Jen, Jie ;

Jindra, Pavel ;

Simkovic, Martin ;

Braester, Andrei ;

Ruchlemer, Rosa ;

Foa, Roberto ;

Semenzato, Gianpietro ;

Hawkins, Timothy ;

Atanasio, Carolina Moreno ;

Demirkan, Fatih ;

Kaynar, Leylagul ;

Pylypenko, Halyna ;

Fox, Christopher ;

Thirman, Michael ;

Campbell, Philip .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (25) :2425-2437

[3] Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia [J].

Byrd, John C. ;

Harrington, Bonnie ;

O'Brien, Susan ;

Jones, Jeffrey A. ;

Schuh, Anna ;

Devereux, Steve ;

Chaves, Jorge ;

Wierda, William G. ;

Awan, Farrukh T. ;

Brown, Jennifer R. ;

Hillmen, Peter ;

Stephens, Deborah M. ;

Ghia, Paolo ;

Barrientos, Jacqueline C. ;

Pagel, John M. ;

Woyach, Jennifer ;

Johnson, Dave ;

Huang, Jane ;

Wang, Xiaolin ;

Kaptein, Allard ;

Lannutti, Brian J. ;

Covey, Todd ;

Fardis, Maria ;

McGreivy, Jesse ;

Hamdy, Ahmed ;

Rothbaum, Wayne ;

Izumi, Raquel ;

Diacovo, Thomas G. ;

Johnson, Amy J. ;

Furman, Richard R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (04) :323-332

[4] Entering the Era of Targeted Therapy for Chronic Lymphocytic Leukemia: Impact on the Practicing Clinician [J].

Byrd, John C. ;

Jones, Jeffrey J. ;

Woyach, Jennifer A. ;

Johnson, Amy J. ;

Flynn, Joseph M. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (27) :3039-3047

[5] Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes [J].

Dubovsky, Jason A. ;

Beckwith, Kyle A. ;

Natarajan, Gayathri ;

Woyach, Jennifer A. ;

Jaglowski, Samantha ;

Zhong, Yiming ;

Hessler, Joshua D. ;

Liu, Ta-Ming ;

Chang, Betty Y. ;

Larkin, Karilyn M. ;

Stefanovski, Matthew R. ;

Chappell, Danielle L. ;

Frissora, Frank W. ;

Smith, Lisa L. ;

Smucker, Kelly A. ;

Flynn, Joseph M. ;

Jones, Jeffrey A. ;

Andritsos, Leslie A. ;

Maddocks, Kami ;

Lehman, Amy M. ;

Furman, Richard ;

Sharman, Jeff ;

Mishra, Anjali ;

Caligiuri, Michael A. ;

Satoskar, Abhay R. ;

Buggy, Joseph J. ;

Muthusamy, Natarajan ;

Johnson, Amy J. ;

Byrd, John C. .

BLOOD, 2013, 122 (15) :2539-2549

[6] Biology of Chronic Lymphocytic Leukemia in Different Microenvironments Clinical and Therapeutic Implications [J].

Herishanu, Yair ;

Katz, Ben-Zion ;

Lipsky, Andrew ;

Wiestner, Adrian .

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2013, 27 (02) :173-+

[7] The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia [J].

Herishanu, Yair ;

Perez-Galan, Patricia ;

Liu, Delong ;

Biancotto, Angelique ;

Pittaluga, Stefania ;

Vire, Berengere ;

Gibellini, Federica ;

Njuguna, Ndegwa ;

Lee, Elinor ;

Stennett, Lawrence ;

Raghavachari, Nalini ;

Liu, Poching ;

McCoy, J. Philip ;

Raffeld, Mark ;

Stetler-Stevenson, Maryalice ;

Yuan, Constance ;

Sherry, Richard ;

Arthur, Diane C. ;

Maric, Irina ;

White, Therese ;

Marti, Gerald E. ;

Munson, Peter ;

Wilson, Wyndham H. ;

Wiestner, Adrian .

BLOOD, 2011, 117 (02) :563-574

[8] Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765 [J].

Herman, Sarah E. M. ;

Gordon, Amber L. ;

Hertlein, Erin ;

Ramanunni, Asha ;

Zhang, Xiaoli ;

Jaglowski, Samantha ;

Flynn, Joseph ;

Jones, Jeffrey ;

Blum, Kristie A. ;

Buggy, Joseph J. ;

Hamdy, Ahmed ;

Johnson, Amy J. ;

Byrd, John C. .

BLOOD, 2011, 117 (23) :6287-6296

[9] Extracellular HMGB1 promotes differentiation of nurse-like cells in chronic lymphocytic leukemia [J].

Jia, Li ;

Clear, Andrew ;

Liu, Feng-Ting ;

Matthews, Janet ;

Uddin, Nadiha ;

McCarthy, Aine ;

Hoxha, Elena ;

Durance, Catherine ;

Iqbal, Sameena ;

Gribben, John G. .

BLOOD, 2014, 123 (11) :1709-1719

[10] Disruption of in vivo Chronic Lymphocytic Leukemia Tumor-Microenvironment Interactions by Ibrutinib - Findings from an Investigator-Initiated Phase II Study [J].

Niemann, Carsten U. ;

Herman, Sarah E. M. ;

Maric, Irina ;

Gomez-Rodriguez, Julio ;

Biancotto, Angelique ;

Chang, Betty Y. ;

Martyr, Sabrina ;

Stetler-Stevenson, Maryalice ;

Yuan, Constance M. ;

Calvo, Katherine R. ;

Braylan, Raul C. ;

Valdez, Janet ;

Lee, Yuh Shan ;

Wong, Deanna H. ;

Jones, Jade ;

Sun, Clare ;

Marti, Gerald E. ;

Farooqui, Mohammed Z. H. ;

Wiestner, Adrian .

CLINICAL CANCER RESEARCH, 2016, 22 (07) :1572-1582

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