Indirect spectrophotometric determination of benzylpenicillin and cloxacillin in pharmaceutical preparations

被引：2
|
作者：
Helaleh, MIH [1 ]
机构：
[1] Aligarh Muslim Univ, Dept Chem, Anal Res Div, Aligarh 202002, Uttar Pradesh, India
来源：
MIKROCHIMICA ACTA | 1998年 / 129卷 / 1-2期
关键词：
benzylpenicillin; cloxacillin; spectrophotometry; pharmaceutical analysis;
D O I：
10.1007/BF01246845
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
An indirect spectrophotometric method for the determination of benzylpenicillin and cloxacillin is based on extraction of iodine produced by reduction of potassium iodate in acidic medium, where hydrolytic cleavage of a beta-lactam is achieved with sodium hydroxide. Beer's law is obeyed within the concentration ranges 0.04-0.8 mg ml(-1) benzylpenicillin and 0.02-0.5 mg ml(-1) cloxacillin. The precision, accuracy of the method and the effect of foreign substances were studied. The results have been statistically compared with those using the ammonium vanadate method. An oxidation mechanism is proposed.
引用
收藏
页码：29 / 32
页数：4
相关论文
共 50 条
  • [31] Spectrophotometric determination of cysteine andN-acetylcysteine in pharmaceutical preparations
    Maher Abu Eid
    Microchimica Acta, 1998, 129 : 91 - 95
  • [32] A Kinetic spectrophotometric method for determination of amlodipine and Nifedipine in pharmaceutical preparations
    B. Hemmateenejad
    R. Miri
    R. Kamali
    Journal of the Iranian Chemical Society, 2009, 6 : 113 - 120
  • [33] Fully automated spectrophotometric method for the determination of buspirone in pharmaceutical preparations
    Ribeiro, Marta F. T.
    Santos, Joao L. M.
    Lima, Jose L. F. C.
    Dias, Ana C. B.
    Zagatto, Elias A. G.
    ANALYTICAL LETTERS, 2006, 39 (11) : 2243 - 2253
  • [34] New Potentiometric and Spectrophotometric Methods for the Determination of Dextromethorphan in Pharmaceutical Preparations
    Mohamed A. F. Elmosallamy
    Alaa S. Amin
    Analytical Sciences, 2014, 30 : 419 - 425
  • [35] Extraction-spectrophotometric determination of mefenamic acid in pharmaceutical preparations
    Zh. A. Kormosh
    O. Yu. Matviichuk
    Ya. R. Bazel’
    Journal of Analytical Chemistry, 2014, 69 : 960 - 964
  • [36] Spectrophotometric determination of carbamazepine and mosapride citrate in pure and pharmaceutical preparations
    Frag, Eman Y. Z.
    Zayed, M. A.
    Omar, M. M.
    Elashery, Sally E. A.
    Mohamed, Gehad G.
    ARABIAN JOURNAL OF CHEMISTRY, 2012, 5 (03) : 375 - 382
  • [37] Use of nitrosation in the spectrophotometric determination of levodopa and methyldopa in pharmaceutical preparations
    Helaleh, MIH
    Abu-Nameh, ESM
    CHEMIA ANALITYCZNA, 1998, 43 (02): : 225 - 230
  • [38] Direct and Indirect Spectrophotometric Methods for Determination of Metronidazole in Pharmaceutical Formulations
    Rashid, Qabas Naji
    EGYPTIAN JOURNAL OF CHEMISTRY, 2023, 66 (02): : 73 - 80
  • [39] KINETIC SPECTROPHOTOMETRIC DETERMINATION OF SOME FLUOROQUINOLONE ANTIBIOTICS IN BULK AND PHARMACEUTICAL PREPARATIONS
    Wahed, Mohammed G. Abdel
    El Sheikh, Ragaa
    Gouda, Ayman A.
    Abou Taleb, Sayed
    BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, 2013, 27 (03) : 329 - 346
  • [40] Flow extraction spectrophotometric method for the determination of diclofenac sodium in pharmaceutical preparations
    PerezRuiz, T
    MartinezLozano, C
    Sanz, A
    SanMiguel, MT
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1997, 16 (02) : 249 - 254
12345