Kiiacylphnols A-H, eight undescribed polycyclic polyprenylated acylphloroglucinols with anticancer activities from Hypericum przewalskii Maxim

被引：4

作者：

Duan, Yulin ^{[1
]}

Hu, Ping ^{[1
]}

Guo, Yi ^{[1
]}

Bu, Pengfei ^{[1
]}

Shi, Zhengyi ^{[1
]}

Cao, Yunfang ^{[1
]}

Zhang, Yeting ^{[1
]}

Hu, Hong ^{[1
]}

Tong, Qingyi ^{[1
]}

Qi, Changxing ^{[1
]}

Zhang, Yonghui ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

来源：

PHYTOCHEMISTRY | 2022年 / 199卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Hypericum przewalskii Maxim; Hypericaceae; Polycyclic polyprenylated acylphloroglucinols; Cytotoxic activity;

D O I：

10.1016/j.phytochem.2022.113166

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Kiiacylphnols A-H, eight previously undescribed polycyclic polyprenylated acylphloroglucinols (PPAPs), along with two known congeners (hyperforcinol F and oxepahyperforin), were obtained from Hypericum przewalskii Maxim. The structures of these metabolites were confirmed by spectroscopic analyses, quantum-chemical 1H and 13C NMR calculations with DP4+ analyses, electronic circular dichroism (ECD) comparisons and calculations. Kiiacylphnols A and B were the first [3.3.1]-type PPAPs with an unusual octahydrooxireno[2,3-i]chromene scaffold bearing a rare 6/6/6/3 ring system. More significantly, kiiacylphnol A and oxepahyperforin displayed cytotoxicity against acute myeloid leukemia and diffuse large B-cell lymphoma cell lines by inducing cell apoptosis.

引用

页数：11

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